Author | Chamon, Raiane Cardoso | |
Author | Rocha, Jaqueline Abel da | |
Author | Martins, Isabella Araujo | |
Author | Pires, Laís Lopes | |
Author | Almeida, Breno Macêdo de | |
Author | Leite, Nahara Souza | |
Author | Souza, Cláudia Rezende Vieira de Mendonça | |
Author | Zahner, Viviane | |
Author | Ribeiro, Rachel Leite | |
Author | Chagas, Thiago Pavoni Gomes | |
Author | Martins, Ianick Souto | |
Access date | 2020-07-24T18:24:17Z | |
Available date | 2020-07-24T18:24:17Z | |
Document date | 2020 | |
Citation | CHAMON, Raiane Cardoso et al. KPC-2 producing Pseudomonas putida as an unexpected pathogen of catheter-associated bloodstream infection. Journal of Infection in Developing Countries, v. 14, n. 4, p. 411-414, 2020. | pt_BR |
ISSN | 2036-6590 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/42378 | |
Language | eng | pt_BR |
Publisher | Journal of Infection in Developing Countries | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Pseudomonas putida | pt_BR |
Subject in Portuguese | Klebsiella pneumoniae carbapenemase | pt_BR |
Subject in Portuguese | Infecção por corrente sanguínea; | pt_BR |
Subject in Portuguese | KPC | pt_BR |
Title | KPC-2 producing Pseudomonas putida as an unexpected pathogen of catheter-associated bloodstream infection | pt_BR |
Type | Article | pt_BR |
DOI | 10.3855/jidc.12145 | |
Abstract | Infections due to multidrug resistant Gram-negative pathogens are of great concern worldwide, as they are frequently associated with high mortality and morbidity rates. The occurrence of Pseudomonas spp. producing Klebsiella pneumoniae carbapenemases (KPCs) imposes a great challenge through treatment course of bloodstream infections (BSIs). Pseudomonas putida has been recognized as an emerging pathogen of healthcare associated infections (HAIs). Therefore, we aimed to report a case of a non-fatal case of peripheral line associated BSI (PLA-BSI) in an immunocompromised host due to P. putida harboring blaKPC-2 gene in Brazil. A P. putida isolate was recovered from a blood culture of a 72-year-old man admitted at a University Hospital, identified by BD Phoenix™ 100 (Becton, Dickinson and Company), causing PLA-BSI. The species identification was confirmed by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) and resistance to carbapenems were confirmed by Epsilometer test (E-test®). Additionally, the presence of important carbapenemases genes (blaKPC, blaNDM, blaOXA-48-like, blaSPM, blaIMP, blaVIM) was investigated by Polymerase Chain Reaction. The bacterial isolate was confirmed as meropenem resistant P. putida harboring blaKPC-2 gene.Thereofre, these fidings suggest that P. putida can work as a reservoir for resistance genes as this bacterium has the ability to disseminate through water-fluids inside hospital and community settings. Moreover, this paper highlights that a frequent and worldwide disseminated mechanism of resistance (blaKPC-2) is currently occurring among uncommon agents of BSI. | pt_BR |
Affilliation | Universidade Federal Fluminense, Escola de Medicina. Departamento de Patologia. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense, Escola de Medicina. Hospital Universitário Antonio Pedro. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense, Escola de Medicina. Hospital Universitário Antonio Pedro. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense, Escola de Medicina. Departamento de Patologia. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense, Escola de Medicina. Departamento de Patologia. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense, Escola de Medicina. Departamento de Patologia. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense, Escola de Medicina. Departamento de Medicina Interna. Seção de Doenças Infecciosas. Niterói, RJ, Brasil / Instituto Nacional de Câncer. Hospital do CÂncer. Comissão de Controle Hospitalar. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Pseudomonas putida | pt_BR |
Subject | Bloodstream infection | pt_BR |
Subject | Klebsiella pneumoniae carbapenemase | pt_BR |
Subject | KPC | pt_BR |
e-ISSN | 1972-2680 | |