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https://www.arca.fiocruz.br/handle/icict/42416
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ArtigoDireito Autoral
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- IOC - Artigos de Periódicos [12500]
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SARS-COV-2 ENVELOPE AND MEMBRANE PROTEINS: STRUCTURAL DIFFERENCES LINKED TO VIRUS CHARACTERISTICS?
Envelope SARS-CoV-2
Proteínas de membrana
Estruturais Diferenças
Características do vírus
COVID-19
Envelope and Membrane proteins
Structural Differences
Virus Characteristics
COVID-19
Autor(es)
Afiliação
Sapienza University of Rome. Department of Biochemical sciences “A Rossi Fanelli”. Rome, Italy.
University Campus Bio-Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
University Campus Bio-Medico of Rome. Unit of Clinical Laboratory Science. Rome, Italy.
University Campus Bio-Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.
Sapienza University of Rome. Department of Biochemical sciences “A Rossi Fanelli”. Rome, Italy.
University Campus Bio-Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
University Campus Bio-Medico of Rome. Unit of Clinical Laboratory Science. Rome, Italy.
University Campus Bio-Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.
Sapienza University of Rome. Department of Biochemical sciences “A Rossi Fanelli”. Rome, Italy.
Resumo em Inglês
The Coronavirus Disease 2019 (COVID-19) is a new viral infection caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2). Genomic analyses have revealed that SARS-CoV-2 is related to Pangolin and Bat coronaviruses. In this report, a structural comparison between the Sars-CoV-2 Envelope and Membrane proteins from different human isolates with homologous proteins from closely related viruses is described. The analyses here reported show the high structural similarity of Envelope and Membrane proteins to the counterparts from Pangolin and Bat coronavirus isolates. However, the comparisons have also highlighted structural differences specific of Sars-CoV-2 proteins which may be correlated to the cross-species transmission and/or to the properties of the virus. Structural modelling has been applied to map the variant sites onto the predicted three-dimensional structure of the Envelope and Membrane proteins.
Palavras-chave
SARS-CoV-2Envelope SARS-CoV-2
Proteínas de membrana
Estruturais Diferenças
Características do vírus
COVID-19
Palavras-chave em inglês
SARS-CoV-2Envelope and Membrane proteins
Structural Differences
Virus Characteristics
COVID-19
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