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EVIDENCE FOR MUTATIONS IN SARS-COV-2 ITALIAN ISOLATES POTENTIALLY AFFECTING VIRUS TRANSMISSION
COVID-19
Evolução molecular
Mutação
Coronavírus SARS
SARS-CoV-2
COVID-19
Molecular evolution
Mutation
SARS coronavirus
SARS-CoV-2
Autor
Afiliación
University Campus Bio‐Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.
Izmir University of Economics. Department of Medical Biology. Izmir, Turkey.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus; Rio de Janeiro, RJ, Brasil.
University of Rome “La Sapienza”. Department of Biochemical Sciences “A. Rossi Fanelli”. Rome, Italy.
University Campus Bio‐Medico of Rome. Unit of Clinical Laboratory Science. Rome, Italy.
University of Rome “La Sapienza”. Department of Biochemical Sciences “A. Rossi Fanelli”. Rome, Italy.
Fondazione Policlinico Universitario “A. Gemelli” IRCCS. Rome, Italy / Catholic University of Sacred Heart. Department of Healthcare Surveillance and Bioethics. Rome, Italy.
University Campus Bio‐Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.
University of Siena. Department of Genomics, Genetics and Biology. Siena, Italy.
Izmir University of Economics. Department of Medical Biology. Izmir, Turkey.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus; Rio de Janeiro, RJ, Brasil.
University of Rome “La Sapienza”. Department of Biochemical Sciences “A. Rossi Fanelli”. Rome, Italy.
University Campus Bio‐Medico of Rome. Unit of Clinical Laboratory Science. Rome, Italy.
University of Rome “La Sapienza”. Department of Biochemical Sciences “A. Rossi Fanelli”. Rome, Italy.
Fondazione Policlinico Universitario “A. Gemelli” IRCCS. Rome, Italy / Catholic University of Sacred Heart. Department of Healthcare Surveillance and Bioethics. Rome, Italy.
University Campus Bio‐Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.
University of Siena. Department of Genomics, Genetics and Biology. Siena, Italy.
Resumen en ingles
Italy is the first western country suffering heavy severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and disease impact after coronavirus disease-2019 pandemia started in China. Even though the presence of mutations on spike glycoprotein and nucleocapsid in Italian isolates has been reported, the potential impact of these mutations on viral transmission has not been evaluated. We have compared SARS-CoV-2 genome sequences from Italian patients with virus sequences from Chinese patients. We focussed upon three nonsynonymous mutations of genes coding for S(one) and N (two) viral proteins present in Italian isolates and absent in Chinese ones, using various bioinformatics tools. Amino acid analysis and changes in three-dimensional protein structure suggests the mutations reduce protein stability and, particularly for S1 mutation, the enhanced torsional ability of the molecule could favor virus binding to cell receptor(s). This theoretical interpretation awaits experimental and clinical confirmation.
Palabras clave en portugues
BioinformáticaCOVID-19
Evolução molecular
Mutação
Coronavírus SARS
SARS-CoV-2
Palabras clave en ingles
BioinformaticsCOVID-19
Molecular evolution
Mutation
SARS coronavirus
SARS-CoV-2
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