Author | Moragas-Tellis, Carla Junqueira | |
Author | Souza, Fernando Almeida | |
Author | Chagas, Maria do Socorro dos Santos | |
Author | Souza, Paulo Victor Ramos de | |
Author | Silva, João Victor Silva | |
Author | Ramos, Ygor Jessé | |
Author | Moreira, Davyson de Lima | |
Author | Calabrese, Kátia da Silva | |
Author | Behrens, Maria Dutra | |
Access date | 2020-09-05T19:50:05Z | |
Available date | 2020-09-05T19:50:05Z | |
Document date | 2020 | |
Citation | MORAGAS-TELLIS, Carla Junqueira et al. The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes. Molecules, v. 23, n. 3547, p. 1-13, 2020. | pt_BR |
ISSN | 1420-3049 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/43194 | |
Language | eng | pt_BR |
Publisher | MDPI | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmania amazonensis | pt_BR |
Subject in Portuguese | Bignoniaceae | pt_BR |
Subject in Portuguese | Antocianinas | pt_BR |
Subject in Portuguese | Estação do ano | pt_BR |
Subject in Portuguese | Perfil fitoquímico | pt_BR |
Title | The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes | pt_BR |
Type | Article | pt_BR |
DOI | 10.3390/molecules25153547 | |
Abstract | Arrabidaea chica Verlot (crajiru) is a plant used in folk medicine as an astringent, anti-inflammatory, wound healing and to treat fungal and viral diseases such as measles chickenpox and herpes. Arrabidaea chica has several morphotypes recognized but little is known about its chemical variability. In the present study the anthocyanidin profile of A. chica morphotypes collected in two seasons (summer and winter) have been examined and their activity against Leishmania infection compared. High-performance liquid chromatography coupled to a diode-array detector (HPLC-DAD-UV) and by tandem mass spectrometry with electrospray ionization (ESI-MS/MS) were used for anthocyanidin separation and identification. Antileishmanial activity was measured against promastigote forms of Leishmania amazonensis. Multivariate analysis, principal component analysis (PCA) and Pearson’s correlation were performed to classify morphotypes accordingly to their anthocyanidin profile. The presence of 6,7,30 ,40 -tetrahydroxy-5-methoxyflavylium (30 -hydroxycarajurone) (1), carajurone (2), 6,7,30 -trihydroxy-5,40 -dimethoxy-flavylium (30 -hydroxy-carajurin) (3) and carajurin (4), and three unidentified anthocyanidins were detected. Two different groups were recognized: group I containing 30 -hydroxy-carajurone; and group II with high content of carajurin. Among anthocyanidins identified in the extracts, only carajurin showed significant statistical correlation (p = 0.030) with activity against L. amazonensis. Carajurin could thus be considered as a pharmacological marker for the antileishmanial potential of the species. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia de Fármacos-Farmanguinhos. Departamento de Produtos Naturais. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil / Universidade Estadual do Maranhão. Pós Graduação em Ciência Animal. São Luis, MA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia de Fármacos-Farmanguinhos. Departamento de Produtos Naturais. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia de Fármacos-Farmanguinhos. Departamento de Produtos Naturais. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia de Fármacos-Farmanguinhos. Departamento de Produtos Naturais. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia de Fármacos-Farmanguinhos. Departamento de Produtos Naturais. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia de Fármacos- armanguinhos. Departamento de Produtos Naturais. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Bignoniaceae | pt_BR |
Subject | Leishmania amazonensis | pt_BR |
Subject | Anthocyanidins | pt_BR |
Subject | Phytochemical profile | pt_BR |
Subject | Season | pt_BR |
Subject | Carajurin | pt_BR |
DeCS | Bignoniaceae | pt_BR |
DeCS | Anthocyanidins | pt_BR |