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FACTORS UNDERLYING THE NATURAL RESISTANCE OF ANIMALS AGAINST SNAKE VENOMS
Autor
Afiliación
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.
Universidad Centro Occidenta, Departamento de Bioquímica. Unidad de Investigación. Barquisimeto, Venezuela.
Universidad Centro Occidenta, Departamento de Bioquímica. Unidad de Investigación. Barquisimeto, Venezuela.
Resumen en ingles
The existence of mammals and reptilia with a natural resistance to snake venoms is known since a long time. This fact has been subjected to the study by several research workers. Our experiments showed us that in the marsupial Didelphis marsupialis, a mammal highly resistant to the venom of Bothrops jararaca, and other Bothrops venoms, has a genetically origin protein, a alpha-1, acid glycoprotein, now highly purified, with protective action in mice against the jararaca snake venom.
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