Author | Boechat, Viviane Cardoso | |
Author | Pereira, Sandro Antonio | |
Author | Mendes Júnior, Artur Augusto Velho | |
Author | Santos, Shanna Araujo dos | |
Author | Miranda, Luciana de Freitas Campos | |
Author | Figueiredo, Fabiano Borges | |
Author | Ferreira, Luiz Claudio | |
Author | Rodrigues, Francisco das Chagas de Carvalho | |
Author | Oliveira, Raquel de Vasconcellos Carvalhaes de | |
Author | Teles -de-Freitas, Rayane | |
Author | Bruno, Rafaela Vieira | |
Author | Morgado, Fernanda Nazaré | |
Author | Menezes, Rodrigo Caldas | |
Access date | 2020-09-22T20:24:52Z | |
Available date | 2020-09-22T20:24:52Z | |
Document date | 2020 | |
Citation | BOECHAT, Viviane Cardoso et al. Frequency, active infection and load of Leishmania infantum and associated histological alterations in the genital tract of male and female dog. PLoS One, v. 15, n. 9, p. 1-18, 2020. | pt_BR |
ISSN | 1932-6203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/43558 | |
Language | por | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Title | Frequency, active infection and load of Leishmania infantum and associated histological alterations in the genital tract of male and female dogs | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pone.0238188 | pt_BR |
Abstract | Visceral leishmaniasis caused by the protozoan Leishmania infantum is a zoonosis. The domestic dog is the primary reservoir in urban areas. This study aimed to evaluate the frequency, active infection and load of L. infantum in the genital tract of male and female dogs seropositive for this parasite, as well as to identify histological genital alterations associated with this protozoan. We studied 45 male and 25 female L. infantum-seropositive non castrated dogs from the same endemic area in Brazil. Tissue samples from the testis, epididymis, prostate, vulva, vagina, and uterus were examined by singleplex qPCR and parasitological tests (histopathology, immunohistochemistry, and parasitological culture). The latter were performed for the detection of active infection (parasites able to multiply and to induce lesions). Forty-four (98%) males and 25 (100%) females were positive for L. infantum in the genital tract (epididymis: 98%; vulva: 92%; vagina: 92%; testis: 91%; uterus: 84%; prostate: 66%). Active infection in the genital tract was confirmed in 69% of males and 64% of females (32% in the uterus). Parasite loads were similar in the testis, vulva, epididymis and vagina and lower in the prostate. Only the parasite load in the vagina was significantly associated with the number of clinical signs. Granulomatous inflammation predominated in all organs, except for the prostate. Only in the testis and epididymis was the inflammatory infiltrate significantly more intense among dogs with a higher parasite load in these organs. The high frequency, detection of active infection and similarity of L. infantum loads in the genital tract of infected males and females suggest the potential of venereal transmission of this parasite by both sexes and of vertical transmission by females in the area studied. Additionally, vertical transmission may be frequent since active L. infantum infection was a common observation in the uterus. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Epidemiologia Clínica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Insetos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Insetos. Rio de Janeiro, RJ, Brasil. / Ministério de Ciência Tecnologia e Inovação. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Leishmaniasis, Visceral | pt_BR |
Subject | Dogs | pt_BR |
Subject | Reproductive Tract Infections | pt_BR |
Subject | Infectious Disease Transmission, Vertical | pt_BR |
Subject in Spanish | Leishmaniasis Visceral | pt_BR |
Subject in Spanish | Perros | pt_BR |
Subject in Spanish | Infecciones del Sistema Genital | pt_BR |
Subject in Spanish | Transmisión Vertical de Enfermedad Infecciosa | pt_BR |
Subject in French | Leishmaniose viscérale | pt_BR |
Subject in French | Chiens | pt_BR |
Subject in French | Infections de l'appareil reproducteur | pt_BR |
Subject in French | Transmission verticale de maladie infectieuse | pt_BR |
DeCS | Leishmaniose Visceral | pt_BR |
DeCS | Cães | pt_BR |
DeCS | Infecções do Sistema Genital | pt_BR |
DeCS | Transmissão Vertical de Doença Infecciosa | pt_BR |