Author | Nicchio, Bianca Oliveira | pt_BR |
Author | Melo, Stella Maria Barrouin | pt_BR |
Author | Machado, Marilia Carneiro | pt_BR |
Author | Vieira Filho, Carlos Humberto | pt_BR |
Author | Santos, Ferlando Lima | pt_BR |
Author | Martins Filho, Emanoel Ferreira | pt_BR |
Author | Barbosa, Vivian Fernanda | pt_BR |
Author | Barral, Thiago Doria | pt_BR |
Author | Portela, Ricardo Wagner | pt_BR |
Author | Damasceno, Karine Araújo | pt_BR |
Author | Lima, Alessandra Estrela | pt_BR |
Access date | 2020-10-16T17:40:14Z | |
Available date | 2020-10-16T17:40:14Z | |
Document date | 2020 | |
Citation | NICCHIO, Bianca Oliveira et al. Hyperresistinemia in obese female dogs with mammary carcinoma in benign-mixed tumors and its correlation with tumor aggressiveness and survival. Frontiers in Veterinary Science, v. 7, n. 509, p. 1-14, 13 Aug. 2020. | pt_BR |
ISSN | 2297-1769 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/44011 | |
Sponsorship | Bahia Research Foundation (FAPESB), 023/2014 PROINTER. BN was a M.Sc. fellow the Coordination for the Improvement of Higher Education Personnel (CAPES - Proc. 1803306). EM-F was a postdoctoral fellow from CAPES (Proc. 88887.310811/2018-00). AE-L (Proc. 305938/2018-5), FS (Proc. 305938/2018-5), and SB-M (Proc. 307813/2018-5) are Research fellows from the National Council for Scientific and Technological Development (CNPq). RP is a Technological Development fellow from CNPq (Proc. 313350/2019-1). | pt_BR |
Language | eng | pt_BR |
Publisher | Frontiers Media | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Citocinas | pt_BR |
Subject in Portuguese | Ki-67 | pt_BR |
Subject in Portuguese | Câncer mamário | pt_BR |
Subject in Portuguese | Sobrevivência | pt_BR |
Subject in Portuguese | Obesidade | pt_BR |
Title | Hyperresistinemia in obese female dogs with mammary carcinoma in benign-mixed tumors and its correlation with tumor aggressiveness and survival | en |
Type | Article | pt_BR |
DOI | 10.3389/fvets.2020.00509 | pt_BR |
Abstract | Resistin is associated with metabolic, inflammatory, and neoplastic disorders, and is also considered a prognostic marker in human oncology. Canine mammary tumors have epidemiological, clinical, biological, and genetic characteristics similar to those of women and are proposed as a comparative study model. Here, we evaluate the serum levels of resistin in female dogs with or without mammary carcinoma in mixed tumors (CBMT) and its correlation with the proliferative potential of the tumor, obesity, and survival. Eighty dogs grouped according to the presence (50) or absence (30) of CBMT, reproductive status and body condition were assessed for weight, fat percentage, and canine body mass index. The characteristic of the proliferative potential of the tumor (Ki-67) was evaluated. Ki-67 levels (p = 0.024), staging (p = 0.004), and grade (p = 0.016) influenced the survival of the female dogs. Through a multifactorial analysis, it could be seen that the parameters proliferation index (Ki-67) (p = 0.044) and staging (p = 0.036) influenced the survival of the animals. Neutered and overweight dogs from the control and CBMT groups showed hyperresistinemia. Ki-67 expression and resistin levels in dogs with CBMT were higher in overweight dogs than in dogs with normal weight (p = 0.0001). The survival rate of dogs with CBMT, obese and with high levels of resistin (8,400 µg L−1) was lower when compared to those with lower levels of resistin. These results showed an important relationship between hyperresistinemia, tumor proliferative potential and excessive body fat, suggesting that resistin levels may act as an interesting prognostic marker in patients with CBMT. | en |
Affilliation | Federal University of Bahia. School of Veterinary Medicine. Salvador, BA, Brazil / Federal University of Bahia. Research Center on Mammary Oncology. Salvador, BA, Brazil. | pt_BR |
Affilliation | Federal University of Bahia. School of Veterinary Medicine. Salvador, BA, Brazil. | pt_BR |
Affilliation | Federal University of Bahia. School of Veterinary Medicine. Salvador, BA, Brazil / Federal University of Bahia. Research Center on Mammary Oncology. Salvador, BA, Brazil. | pt_BR |
Affilliation | Federal University of Bahia. School of Veterinary Medicine. Salvador, BA, Brazil / Federal University of Bahia. Research Center on Mammary Oncology. Salvador, BA, Brazil. | pt_BR |
Affilliation | Federal University of the Recôncavo of Bahia. Health Science Center. Santo Antônio de Jesus, BA, Brazil. | pt_BR |
Affilliation | Federal University of Bahia. School of Veterinary Medicine. Salvador, BA, Brazil / Federal University of Bahia. Research Center on Mammary Oncology. Salvador, BA, Brazil. | pt_BR |
Affilliation | Federal University of Bahia. School of Veterinary Medicine. Salvador, BA, Brazil. | pt_BR |
Affilliation | Federal University of Bahia. Institute of Health Sciences. Laboratory of Immunology and Molecular Biology. Salvador, BA, Brazil. | pt_BR |
Affilliation | Federal University of Bahia. Research Center on Mammary Oncology. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. | pt_BR |
Affilliation | Federal University of Bahia. School of Veterinary Medicine. Salvador, BA, Brazil / Federal University of Bahia. Research Center on Mammary Oncology. Salvador, BA, Brazil. | pt_BR |
Subject | Adipocytokines | pt_BR |
Subject | Ki-67 | pt_BR |
Subject | Mammary cancer | pt_BR |
Subject | Survival | pt_BR |
Subject | Obesity | pt_BR |
Subject | Prognostic marker | pt_BR |