Mostrar el registro sencillo del ítem
Autor | Cardoso, Camila Almeida | |
Autor | Araujo, Gabriela V | |
Autor | Sandoval, Carmen M | |
Autor | Nogueira, Paula Monalisa | |
Autor | Zúniga, Concepcion | |
Autor | Sosa-Ochoa, Wilfredo H | |
Autor | Laurenti, Márcia D | |
Autor | Soares, Rodrigo Pedro Pinto | |
Fecha de acceso | 2020-10-20T15:51:30Z | |
Fecha de disponibilización | 2020-10-20T15:51:30Z | |
Fecha de publicación | 2020 | |
Referencia | CARDOSO, Camila Almeida et al. Lipophosphoglycans from dermotropic Leishmania infantum are more pro-inflammatory than those from viscerotropic strains. Mem. Inst. Oswaldo Cruz, v. 115, e200140, 2020 | pt_BR |
ISSN | 0074-0276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/44080 | |
Idioma | eng | pt_BR |
Editor | Fundação Oswaldo Cruz | pt_BR |
Derechos de autor | open access | pt_BR |
Título | Lipophosphoglycans from dermotropic Leishmania infantum are more pro-inflammatory than those from viscerotropic strains | pt_BR |
Tipo del documento | Article | pt_BR |
DOI | 10.1590/0074-02760200140 | |
Resumen en Inglés | Although Leishmania infantum is well-known as the aethiological agent of visceral leishmaniasis (VL), in some Central American countries it may cause atypical non-ulcerated cutaneous leishmaniasis (NUCL). However, the mechanisms favoring its establishment in the skin are still unknown. Lipophosphoglycan (LPG) is the major Leishmania multivirulence factor involved in parasite-host interaction. In the case of viscerotropic L. infantum, it causes an immunosuppression during the interaction with macrophages. Here, we investigated the biochemical and functional roles of LPGs from four dermotropic L. infantum strains from Honduras during in vitro interaction with murine macrophages. LPGs were extracted, purified and their repeat units analysed. They did not have side chains consisting of Gal(β1,4)Man(α1)-PO4 common to all LPGs. Peritoneal macrophages from BALB/c and C57BL/6 were exposed to LPG for nitric oxide (NO) and cytokine (TNF-α and, IL-6) production. LPGs from dermotropic strains from Honduras triggered higher NO and cytokine levels compared to those from viscerotropic strains. In conclusion, LPGs from dermotropic strains are devoid of side-chains and exhibit high pro-inflammatory activity. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Afiliación | Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia. Laboratório de Patologia de Moléstias Infecciosas. São Paulo, SP, Brasil | pt_BR |
Afiliación | Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia. Laboratório de Patologia de Moléstias Infecciosas. São Paulo, SP, Brasil | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Afiliación | Hospital Escuela Universitario. Departamento de Vigilancia de la Salud. Tegucigalpa, Honduras | pt_BR |
Afiliación | Universidad Nacional Autónoma de Honduras. Instituto de Investigación en Microbiología. Tegucigalpa, Honduras | pt_BR |
Afiliación | Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia. Laboratório de Patologia de Moléstias Infecciosas. São Paulo, SP, Brasil | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Palavras clave en Inglês | lipophosphoglycan | pt_BR |
Palavras clave en Inglês | Leishmania infantum | pt_BR |
Palavras clave en Inglês | innate immunity | pt_BR |