Author | Ferreira, J. Oliveira | |
Author | Daniel-Ribeiro, Claudio Tadeu | |
Access date | 2020-10-22T14:22:58Z | |
Available date | 2020-10-22T14:22:58Z | |
Document date | 2001 | |
Citation | FERREIRA, J. Oliveira; DANIEL-RIBEIRO, Claudio Tadeu. Protective CD8+ T Cell Responses against the Preerythrocytic Stages of Malaria Parasites: an Overview. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 96, n. 2, p. 221-227, Feb. 2001. | pt_BR |
ISSN | 0074-0276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/44114 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Respostas de linfócitos T citotóxicos (CTL) | pt_BR |
Subject in Portuguese | CTL e peptídeos auxiliares | pt_BR |
Subject in Portuguese | Epítopos CD8 + e CD4 + | pt_BR |
Subject in Portuguese | Vetores recombinantes | pt_BR |
Subject in Portuguese | Partículas semelhantes a vírus Ty (VLP) | pt_BR |
Title | Protective CD8+ T Cell Responses against the Pre-erythrocytic Stages of Malaria Parasites: an Overview | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/S0074-02762001000200014 | |
Abstract | CD8+ T cells have been implicated as critical effector cells in protection against the pre-erythrocytic stage of malaria in mice and humans following irradiated sporozoite immunization. Immunization
experiments in animal models by several investigators have suggested different strategies for vaccination against malaria and many of the targets from liver stage malaria antigens have been shown to be
immunogenic and to protect mice from the sporozoite challenge. Several prime/boost protocols with
replicating vectors, such as vaccinia/influenza, with non-replicating vectors, such as recombinant particles derived from yeast transposon (Ty-particles) and modified vaccinia virus Ankara, and DNA, significantly enhanced CD8+ T cell immunogenicity and also the protective efficacy against the
circumsporosoite protein of Plasmodium berghei and P. yeti. Based on these experimental results the
development of a CD8+ T cell inducing vaccine has moved forward from epitope identification to planning stages of safety and immunogenicity trials of candidate vaccines. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Centro Colaborador para Pesquisa e Treinamento em Imunologia de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Centro Colaborador para Pesquisa e Treinamento em Imunologia de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Cytotoxic T lymphocyte (CTL) responses | pt_BR |
Subject | CTL and helper peptides | pt_BR |
Subject | CD8+ and CD4+ epitopes | pt_BR |
Subject | Recombinant vectors | pt_BR |
Subject | Ty-virus like particles (VLP) | pt_BR |
e-ISSN | 1678-8060 | |