| Author | Post, Paulo Roberto | |
| Author | Carvalho, Ricardo de | |
| Author | Freire, Marcos da Silva | |
| Author | Galler, Ricardo | |
| Access date | 2020-10-23T19:55:49Z | |
| Available date | 2020-10-23T19:55:49Z | |
| Document date | 2001 | |
| Citation | POST, Paulo Roberto et al. The Early Use of Yellow Fever Virus Strain 17D for Vaccine Production in Brazil A Review, Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 96, n. 6, p. 849-857, Aug. 2001. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44153 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Febre Amarela | pt_BR |
| Subject in Portuguese | Vacina | pt_BR |
| Subject in Portuguese | Imunização | pt_BR |
| Subject in Portuguese | Tensão 17DD | pt_BR |
| Subject in Portuguese | Linhagem de vírus | pt_BR |
| Title | The Early Use of Yellow Fever Virus Strain 17D for Vaccine Production in Brazil A Review | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/S0074-02762001000600019 | |
| Abstract | The use of yellow fever (YF) virus 17D strain for vaccine production adapted in Brazil since its
introduction in 1937 was reviewed. This was possible due to the availability of official records of vaccine production. The retrieved data highlight the simultaneous use of several serially passaged 17D
substrain viruses for both inocula and vaccine preparation that allowed uninterrupted production. Substitution of these substrain viruses became possible with the experience gained during quality control
and human vaccination. Post-vaccinal complications in humans and the failure of some viruses in quality control tests (neurovirulence for monkeys) indicated that variables needed to be reduced during
vaccine production, leading to the development of the seed lot system. The 17DD substrain, still used
today, was the most frequently used substrain and the most reliable in terms of safety and efficacy. For
this reason, it is possible to derive an infectious cDNA clone of this substrain combined with production
in cell culture that could be used to direct the expression of heterologous antigens and lead to the
development of new live vaccines. | pt_BR |
| Affilliation | Universidade Federal de Pelotas, Campus Universitário. Instituto de Biologia. Departamento de Microbiologia e Parasitologia, Pelotas, RS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Yellow fever | pt_BR |
| Subject | Vaccine | pt_BR |
| Subject | 17DD strain | pt_BR |
| Subject | Virus lineage | pt_BR |
| Subject | Immunization | pt_BR |
| e-ISSN | 1678-8060 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
