Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/44267
A MULTI-PUMP MAGNETOHYDRODYNAMICS LAB-ON-A-CHIP DEVICE FOR AUTOMATED FLOW CONTROL AND ANALYTE DELIVERY
Dispositivos Laboratorio en un Chip
Análisis de Inyección de Flujo
Author
Affilliation
Universidade Federal de Uberlândia. Instituto de Química. Uberlândia, MG, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.
Universidade Federal de Uberlândia. Instituto de Química. Uberlândia, MG, Brasil.
Department of Chemistry. Clemson University. Clemson, USA.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.
Universidade Federal de Uberlândia. Instituto de Química. Uberlândia, MG, Brasil.
Department of Chemistry. Clemson University. Clemson, USA.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.
Abstract
This article shows the development of a computer-controlled lab-on-a-chip device with three magnetohydrodynamic (MHD) pumps and a pneumatic valve. The chip was made of a stack of layers of polymethylmethacrylate (PMMA), cut using a laser engraver and thermally bonded.
The MHD pumps were built using permanent magnets (neodymium) and platinum electrodes, all of them controlled by an Arduino board and a set of relays. The implemented pumps were able to drive solutions in the open channels with a flow rate that increased proportionally with the channel width and applied voltage. To address the characteristic low pressures generated by this kind of pump, all channels were interconnected. Because the electrodes were immersed in the electrolyte, causing electrolysis and pH variations, the composition and ionic strength of the electrolyte solution were controlled. Additionally, side structures for releasing bubbles were integrated. With this multi-pump and valve solution, the device was used to demonstrate the possibility of performing an injection sequence in a system that resembles a traditional flow injection analysis system. Ultimately, the results demonstrate the possibility of performing injection sequences using an array of MHD pumps that can perform fluid handling in the 0–5 µL s−1 range.
Keywords in Spanish
Modelos HidrodinámicosDispositivos Laboratorio en un Chip
Análisis de Inyección de Flujo
Share