Use este identificador para citar ou linkar para este item:
https://www.arca.fiocruz.br/handle/icict/44312
Tipo de documento
ArtigoDireito Autoral
Acesso aberto
Coleções
- INI - Artigos de Periódicos [3397]
- IOC - Artigos de Periódicos [12500]
Metadata
Mostrar registro completo
ISOLATED INTRACRANIAL HYPERTENSION ASSOCIATED WITH COVID-19
SARS-CoV-2
Intracranial hypertension
Pseudotumor cerebri
Headache
GENOMAHCOV
Autor(es)
Afiliação
Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil / Niteroi Hospital Complex. Neurology Department. Niteroi, RJ, Brazil.
Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil / Clementino Fraga Filho University Hospital. Neurology Section. Rio de Janeiro, RJ, Brazil.
Fluminense Federal University. Neurology Department. Niteroi, RJ, Brazil.
Hospital Federal dos Servidores do Estado. Rio de Janeiro, RJ, Brazil.
Eye Hospital. Niteroi, RJ, Brazil.
Neurolife Laboratory. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil / Niteroi Hospital Complex. Neurology Department. Niteroi, RJ, Brazil.
Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Respiratory Virus and Measles. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil / Niteroi Hospital Complex. Neurology Department. Niteroi, RJ, Brazil / Federal University of Rio de Janeiro. Institute of Neurology. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil / Clementino Fraga Filho University Hospital. Neurology Section. Rio de Janeiro, RJ, Brazil.
Fluminense Federal University. Neurology Department. Niteroi, RJ, Brazil.
Hospital Federal dos Servidores do Estado. Rio de Janeiro, RJ, Brazil.
Eye Hospital. Niteroi, RJ, Brazil.
Neurolife Laboratory. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil / Niteroi Hospital Complex. Neurology Department. Niteroi, RJ, Brazil.
Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Respiratory Virus and Measles. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil / Niteroi Hospital Complex. Neurology Department. Niteroi, RJ, Brazil / Federal University of Rio de Janeiro. Institute of Neurology. Rio de Janeiro, RJ, Brazil.
Resumo em Inglês
Background: Headache is a frequent complaint in COVID-19 patients. However, no detailed information on headache characteristics is provided in these reports. Our objective is to describe the characteristics of headache and the cerebrospinal fluid (CSF) profile in COVID-19 patients, highlighting the cases of isolated intracranial hypertension. Methods: In this cross-sectional study, we selected COVID-19 patients who underwent lumbar puncture due to neurological complaints from April to May 2020. We reviewed clinical, imaging, and laboratory data of patients with refractory headache in the absence of other encephalitic or meningitic features. CSF opening pressures higher than 250 mmH2O were considered elevated, and from 200 to 250 mmH2O equivocal. Results: Fifty-six COVID-19 patients underwent lumbar puncture for different neurological conditions. A new, persistent headache that prompted a CSF analysis was diagnosed in 13 (23.2%). The pain was throbbing, holocranial or bilateral in the majority of patients. All patients had normal CSF analysis and RT-qPCR for SARS-CoV-2 was negative in all samples. Opening pressure >200 mmH2O was present in 11 patients and, in six of these, > 250 mmH2O. 6/13 patients had complete improvement of the pain, five had partial improvement, and two were left with a daily persistent headache. Conclusions: In a significant proportion of COVID-19 patients, headache was associated to intracranial hypertension in the absence of meningitic or encephalitic features. Coagulopathy associated with COVID-19 could be an explanation, but further studies including post-mortem analysis of areas of production and CSF absorption (choroid plexuses and arachnoid granulations) are necessary to clarify this issue.
Palavras-chave em inglês
COVID-19SARS-CoV-2
Intracranial hypertension
Pseudotumor cerebri
Headache
GENOMAHCOV
Compartilhar