Author | Lima-Setta, Fernanda | pt_BR |
Author | Magalhães-Barbosa, Maria Clara de | pt_BR |
Author | Rodrigues-Santos, Gustavo | pt_BR |
Author | Figueiredo, Elaine Augusta das Neves | pt_BR |
Author | Jacques, Melissa de Lorena | pt_BR |
Author | Zeitel, Raquel de Seixas | pt_BR |
Author | Sapolnik, Roberto | pt_BR |
Author | Borges, Cibelle Teixeira da Siva | pt_BR |
Author | Lanziotti, Vanessa Soares | pt_BR |
Author | Castro, Roberta Esteves Vieira de | pt_BR |
Author | Bellinat, Ana Paula Novaes | pt_BR |
Author | Silva, Thiago Peres da | pt_BR |
Author | Oliveira, Felipe Rezende Caino de | pt_BR |
Author | Reis, Bárbara Carvalho Santos dos | pt_BR |
Author | Castro, Natália Almeida de Arnaldo Silva Rodriguez | pt_BR |
Author | Macedo, João Henrique Garcia Cobas | pt_BR |
Author | Scarlato, Ana Carolina Cabral Pinheiro | pt_BR |
Author | Riveiro, Paula Marins | pt_BR |
Author | Mota, Isabele Coelho Fonseca da | pt_BR |
Author | Lorenzo, Vivian Botelho | pt_BR |
Author | Lucena, Natalia Martins Lima de | pt_BR |
Author | Azevedo, Zina Maria Almeida de | pt_BR |
Author | Cunha, Antonio José Ledo Alves | pt_BR |
Author | Prata-Barbosa, Arnaldo | pt_BR |
Access date | 2020-11-24T15:36:38Z | |
Available date | 2020-11-24T15:36:38Z | |
Document date | 2020 | |
Citation | LIMA-SETTA, Fernanda et al. Multisystem inflammatory syndrome in children (MIS-C) during SARS-CoV-2 pandemic in Brazil: a multicenter, prospective cohort study. Jornal de Pediatria, p. 1-8, 9 Nov. 2020. | pt_BR |
ISSN | 0021-7557 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/44605 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Later version | https://www.arca.fiocruz.br/handle/icict/51479 | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | SARS-CoV-2 | pt_BR |
Subject in Portuguese | Síndrome inflamatória multissistema em crianças | pt_BR |
Subject in Portuguese | MIS-C | pt_BR |
Subject in Portuguese | Coronavírus | pt_BR |
Subject in Portuguese | COVID-19 | pt_BR |
Subject in Portuguese | Crianças | pt_BR |
Title | Multisystem inflammatory syndrome in children (MIS-C) during SARS-CoV-2 pandemic in Brazil: a multicenter, prospective cohort study (preprint) | en |
Type | Preprint | pt_BR |
DOI | 10.1016/j.jped.2020.10.008 | pt_BR |
Abstract | Objective: To describe the clinical, laboratory, and radiological characteristics, as well as theoutcomes of children with MIS-C. Method: Multicenter, prospective cohort study, conducted in 17 pediatric intensive care units in five states in Brazil, from March to July 2020. Patients from 1 month to 19 years who met the MIS-C diagnostic criteria were included consecutively. Results: Fifty-six patients were included, with the following conditions: Kawasaki-like disease(n = 26), incomplete Kawasaki disease (n = 16), acute cardiac dysfunction (n = 10), toxic shock syndrome (n = 3), and macrophage activation syndrome (n = 1). Median age was 6.2 years (IQR2.4−10.3), 70% were boys, 59% were non-whites, 20% had comorbidities, 48% reported a contact with COVID-19 cases, and 55% had a recent SARS-CoV-2 infection confirmed by RT-PCR and/or serology. Gastrointestinal symptoms were present in 71%, shock symptoms in 59%, and severe respiratory symptoms in less than 20%. d-Dimer was increased in 80% and cardiac dysfunction markers in more than 75%. Treatment included immunoglobulin (89%); corticosteroids, antibi-otics, and enoxaparin in about 50%; and oseltamivir and antifungal therapy in less than 10%. Only 11% needed invasive mechanical ventilation, with a median duration of five days (IQR 5---6.5). The median length of PICU stay was six days (IQR 5---11), and one death occurred (1.8%). Conclusions: Most characteristics of the present MIS-C patients were similar to that of other cohorts. The present results may contribute to a broader understanding of SARS-CoV-2 infection in children and its short-term consequences. Long-term multidisciplinary follow-up is needed, since it is not known whether these patients will have chronic cardiac impairment or other sequelae. | en |
Affilliation | Instituto D'Or de Pesquisa e Ensino. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Unidade de Pacientes Graves. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto D'Or de Pesquisa e Ensino. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto D'Or de Pesquisa e Ensino. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital Pediátrico Unimed. Belém, PA, Brasil. | pt_BR |
Affilliation | Hospital Quinta D'Or. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital São Rafael. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospital São Camilo Cura d'Ars. Fortaleza, PE, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital Martagão Gesteira. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospital Real D'Or. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital Alvorada Moema. Moema, SP, Brasil. | pt_BR |
Affilliation | Complexo Hospitalar de Niterói. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Hospital da Criança. Faculdade de Medicina. Departamento de Pediatria. São José do Rio Preto, SP, Brasil. | pt_BR |
Affilliation | Hospital Copa D'Or. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital Rios D'Or. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital Caxias D'Or. Duque de Caxias, RJ, Brasil. | pt_BR |
Affilliation | Hospital Pro Criança Jutta Batista. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital Couto Maia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospital Monte Klinikum. Fortaleza, CE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Unidade de Pacientes Graves. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto D'Or de Pesquisa e Ensino. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto D'Or de Pesquisa e Ensino. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | SARS-CoV-2 | en |
Subject | Multisystem inflammatory syndrome in children | en |
Subject | MIS-C | en |
Subject | Coronavirus | en |
Subject | COVID-19 | en |
Subject | Children | en |
Peer reviewed | Não | pt_BR |
Publication status | Publicado | pt_BR |