Author | Costa, Monique Melo | |
Author | Campos, Kauara Brito | |
Author | Brito, Luiz Paulo | |
Author | Roux, Emmanuel | |
Author | Rodovalho, Cynara Melo | |
Author | Bellinato, Diogo Fernandes | |
Author | Lima, José Bento Pereira | |
Author | Martins, Ademir Jesus | |
Access date | 2020-12-16T18:43:37Z | |
Available date | 2020-12-16T18:43:37Z | |
Document date | 2020 | |
Citation | COSTA, Monique Melo et al. Kdr genotyping in Aedes aegypti from Brazil on a nation-wide scale from 2017 to 2018. Sci Rep., v. 10, n. 1, 13267, 12p. Aug. 2020. | pt_BR |
ISSN | 2045-2322 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/44943 | |
Language | por | pt_BR |
Publisher | Nature Research | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Aedes aegypti | pt_BR |
Subject in Portuguese | Genotipagem de Kdr | pt_BR |
Subject in Portuguese | Escala Nacional | pt_BR |
Subject in Portuguese | Brasil | pt_BR |
Subject in Portuguese | 2017 a 2018 | pt_BR |
Title | Kdr genotyping in Aedes Aegypti from Brazil on a nation-wide scale from 2017 and 2018 | pt_BR |
Type | Article | pt_BR |
DOI | 10.1038/s41598-020-70029-7 | |
Abstract | Insecticide resistance is currently a threat to the control of Aedes agypti, the main vector of arboviruses in urban centers. Mutations in the voltage gated sodium channel (NaV), known as kdr (knockdown resistance), constitute an important selection mechanism for resistance against pyrethroids. In the present study, we investigated the kdr distribution for the Val1016Ile and Phe1534Cys alterations in Ae. aegypti from 123 Brazilian municipalities, based on SNP genotyping assays in over 5,500 mosquitoes. The alleles NaVS (1016Val+ + 1534Phe+), NaVR1 (1016Val+ + 1534Cyskdr) and NaVR2 (1016Ilekdr + 1534Cyskdr) were consistently observed, whereas kdr alleles have rapidly spread and increased in frequency. NaVS was the less frequent allele, mostly found in Northeastern populations. The highest allelic frequencies were observed for NaVR1, especially in the North, which was fixed in one Amazonian population. The double kdr NaVR2 was more prevalent in the Central-west and South-eastern populations. We introduce the 'kdr index', which revealed significant spatial patterns highlighting two to three distinct Brazilian regions. The 410L kdr mutation was additionally evaluated in 25 localities, evidencing that it generally occurs in the NaVR2 allele. This nationwide screening of a genetic mechanism for insecticide resistance is an important indication on how pyrethroid resistance in Ae. aegypti is evolving in Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade de Brasília. Faculdade de Medicina. Laboratório de Parasitologia Médica e Biologia de Vetores. Brasília, DF, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | ESPACE-DEV, IRD. Université de Montpellier. Université de La Réunion. Université de la Guyane and Université des Antilles, Montpellier, France / Fundação Oswaldo Cruz. aboratório Misto Internacional "Sentinela". Unb, IRD. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil / ESPACE-DEV, IRD. Université de Montpellier. Université de La Réunion. Université de la Guyane and Université des Antilles, Montpellier, France / Fundação Oswaldo Cruz. aboratório Misto Internacional "Sentinela". Unb, IRD. Rio de Janeiro, RJ, Brasil / Universidade federal do Rio de Janeiro. Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Aedes aegypti | pt_BR |
Subject | Kdr genotyping | pt_BR |
Subject | Nation-wide scale | pt_BR |
Subject | from 2017 to 2018 | pt_BR |
Subject | Brazil | pt_BR |