Author | Avanzi, Charlotte | |
Author | Maia, Raquel Cristina | |
Author | Benjak, Andrej | |
Author | Nery, José Augusto | |
Author | Sales, Anna Maria | |
Author | Miranda, Alice | |
Author | Duppre, Nádia Cristina | |
Author | Brum, Amanda Fontes | |
Author | Silva, Tatiana Pereira da | |
Author | Pinheiro, Roberta Olmo | |
Author | Manta, Fernanda Neves | |
Author | Moreira, Suelen Justo Maria | |
Author | Busso, Philippe | |
Author | Sarno, Euzenir Nunes | |
Author | Suffys, Philip | |
Author | Cole, Stewart T. | |
Author | Moraes, Milton Ozório | |
Access date | 2020-12-23T11:51:24Z | |
Available date | 2020-12-23T11:51:24Z | |
Document date | 2020 | |
Citation | AVANZI, Charlotte et al. Emergence of Mycobacterium leprae rifampicin resistance evaluated by whole-genome sequencing after 48 years of irregular treatment. Antimicrob. Agents Chemother, p. 1-13, Apr. 2020. | pt_BR |
ISSN | 0066-4804 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/45088 | |
Language | eng | pt_BR |
Publisher | Oxford Academic | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Mycobacterium leprae | pt_BR |
Subject in Portuguese | Hanseníase | pt_BR |
Subject in Portuguese | Surgimento de recaída | pt_BR |
Subject in Portuguese | Resistência | pt_BR |
Subject in Portuguese | Rifampin | pt_BR |
Subject in Portuguese | Tratamento | pt_BR |
Subject in Portuguese | Sequenciamento de genoma inteiro | pt_BR |
Title | Emergence of MYcobacterium leprae rifampicin resistance evaluated by whole-genome sequencing after 48 years of irregular treatment | pt_BR |
Type | Preprint | pt_BR |
DOI | 10.1128/AAC.00330-20 | pt_BR |
Abstract | A case of Mycobacterium leprae rifampin resistance after irregular antileprosy treatments since 1971 is reported. Whole-genome sequencing from four longitudinal samples indicated relapse due to acquired rifampin resistance and not to reinfection with another strain. A putative compensatory mutation in rpoC was also detected. Clinical improvement was achieved using an alternative therapy. | pt_BR |
Affilliation | Global Health Institute, École Polytechnique Fédérale de Lausanne. Lausanne, Switzerland. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Global Health Institute, École Polytechnique Fédérale de Lausanne. Lausanne, Switzerland. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Global Health Institute, École Polytechnique Fédérale de Lausanne. Lausanne, Switzerland. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Global Health Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland / Institut Pasteur, Paris, France. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Mycobacterium leprae | pt_BR |
Subject | Leprosy | pt_BR |
Subject | Relapse emergence | pt_BR |
Subject | Resistance | pt_BR |
Subject | Rifampin | pt_BR |
Subject | Treatment | pt_BR |
Subject | Whole-genome sequencing. | pt_BR |