Author | Tonini, Marco André Loureiro | |
Author | Barreira, Débora Maria Pires Gonçalves | |
Author | Santolin, Luciana Bueno de Freitas | |
Author | Volpini, Lays Paula Bondi | |
Author | Leite, José Paulo G. | |
Author | Le Moullac-Vaidye, Béatrice | |
Author | Le Pendu, Jacques | |
Author | Spano, Liliana Cruz | |
Access date | 2021-01-13T19:27:50Z | |
Available date | 2021-01-13T19:27:50Z | |
Document date | 2020 | |
Citation | TONINI, Marco André Loureiro et al. FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil. Viruses, v. 12, p. 1-14, Sept. 2020. | pt_BR |
ISSN | 1999-4915 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/45673 | |
Language | eng | pt_BR |
Publisher | MDPI | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Suscetibilidade do hospedeiro | pt_BR |
Subject in Portuguese | Antígenos do grupo histo-sangue (HBGAs) | pt_BR |
Subject in Portuguese | Norovírus | pt_BR |
Subject in Portuguese | Rotavírus | pt_BR |
Subject in Portuguese | Polimorfismos de FUT2 e FUT3 | pt_BR |
Title | FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil | pt_BR |
Type | Article | pt_BR |
DOI | 10.3390/v12101084 | |
Abstract | Host susceptibility according to human histo-blood group antigens (HBGAs) is widely
known for norovirus infection, but is less described for rotavirus. Due to the variable HBGA
polymorphism among populations, we aimed to evaluate the association between HBGA phenotypes
(ABH, Lewis and secretor status) and susceptibility to rotavirus and norovirus symptomatic infection,
and the polymorphisms of FUT2 and FUT3, of children from southeastern Brazil. Paired fecal-buccal
specimens from 272 children with acute diarrhea were used to determine rotavirus/norovirus
genotypes and HBGAs phenotypes/genotypes, respectively. Altogether, 100 (36.8%) children were
infected with rotavirus and norovirus. The rotavirus P[8] genotype predominates (85.7%). Most of the
noroviruses (93.8%) belonged to genogroup II (GII). GII.4 Sydney represented 76% (35/46) amongst
five other genotypes. Rotavirus and noroviruses infected predominantly children with secretor status
(97% and 98.5%, respectively). However, fewer rotavirus-infected children were Lewis-negative (8.6%)
than the norovirus-infected ones (18.5%). FUT3 single nucleotide polymorphisms (SNP) occurred
mostly at the T59G > G508A > T202C > C314T positions. Our results reinforce the current knowledge
that secretors are more susceptible to infection by both rotavirus and norovirus than non-secretors.
The high rate for Lewis negative (17.1%) and the combination of SNPs, beyond the secretor status,
may reflect the highly mixed population in Brazil. | pt_BR |
Affilliation | Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Laboratório de Virologia e Gastroenterite Infecciosa. Maruipe, Vitória, ES, Brasil. | pt_BR |
Affilliation | Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Laboratório de Virologia e Gastroenterite Infecciosa. Maruipe, Vitória, ES, Brasil. | pt_BR |
Affilliation | Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Laboratório de Virologia e Gastroenterite Infecciosa. Maruipe, Vitória, ES, Brasil. | pt_BR |
Affilliation | Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Laboratório de Virologia e Gastroenterite Infecciosa. Maruipe, Vitória, ES, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | CRCINA, Inserm, Université de Nantes. France. | pt_BR |
Affilliation | CRCINA, Inserm, Université de Nantes. France. | pt_BR |
Affilliation | Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Laboratório de Virologia e Gastroenterite Infecciosa. Maruipe, Vitória, ES, Brasil. | pt_BR |
Subject | Host susceptibility | pt_BR |
Subject | Histo-blood group antigens (HBGAs) | pt_BR |
Subject | Norovirus | pt_BR |
Subject | Rotavirus | pt_BR |
Subject | Secretor status | pt_BR |
Subject | Polymorphisms of FUT2 and FUT3 | pt_BR |
Subject | Lewis | pt_BR |