Author | Marcolino, Milena Soriano | |
Author | Ziegelmann, Patricia K. | |
Author | Souza-Silva, Maira V.R. | |
Author | Nascimento, Israel J. Borges do | |
Author | Oliveira, Luana M. | |
Author | Monteiro, Luanna S. | |
Author | Sales, Thaís L.S. | |
Author | Ruschel, Karen B. | |
Author | Martins, Karina P. M. P. | |
Author | Etges, Ana Paula B. S. | |
Author | Molina, Israel | |
Author | Polanczyk, Carisi A. | |
Author | Brazilian COVID-19 | |
Access date | 2021-01-29T16:46:20Z | |
Available date | 2021-01-29T16:46:20Z | |
Document date | 2021 | |
Citation | MARCOLINO, Milena Soriano et al. Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: results from the Brazilian COVID-19 Registry. International Journal of Infectious Diseases, p. 1-51, 2021. | pt_BR |
ISSN | 1201-9712 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/45874 | |
Description | Since January 2020 Elsevier has created a COVID-19 resource centre with
free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | COVID-19 | pt_BR |
Subject in Portuguese | SARS-CoV-2 | pt_BR |
Subject in Portuguese | Hospitalizações | pt_BR |
Subject in Portuguese | Pandemia | pt_BR |
Subject in Portuguese | Brazil | pt_BR |
Subject in Portuguese | Mortality | pt_BR |
Subject in Portuguese | Disease progression | pt_BR |
Title | Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: results from the Brazilian COVID-19 Registry | pt_BR |
Type | Preprint | pt_BR |
DOI | 10.1016/j.ijid.2021.01.019 | |
Abstract | Objectives: To describe clinical characteristics, laboratory and imaging findings, as well as in-hospital outcomes of COVID-19 patients admitted to Brazilian hospitals. Methods: Cohort study of laboratory-confirmed COVID-19 patients hospitalized from March to September 2020 at 25 hospitals. Study data were collected from medical records using Research Electronic Data Capture (REDCap) tools. Multivariate Poisson regression model was used to assess risk factors for in-hospital mortality. Results: Of 2054 patients (52.6% male, median age 58 years old), in-hospital mortality was 22.0%, and 47.6% among those treated in the ICU. Hypertension (52.9%), diabetes (29.2%) and obesity (17.2%) were the most prevalent comorbidities. Overall, 32.5% required invasive mechanical ventilation and 12.1% kidney replacement therapy. Septic shock was observed in 15.0%, nosocomial infection in 13.1%, thromboembolism in 4.1% and acute heart failure in 3.6%. Age ≥65 years-old, chronic kidney disease, hypertension, C-reactive protein ≥100 mg/dL, platelet count <100 × 109/L, oxygen saturation <90%, supplementary oxygen requirement and invasive mechanical ventilation at admission were independently associated with a higher risk of in-hospital mortality. The overall use of antimicrobials was 87.9%. Conclusions: This study provides characteristics and in-hospital outcomes of consecutively hospitalized patients with confirmed COVID-19 in Brazil. Easily assessed parameters at hospital admission were independently associated with a higher risk of death. The high frequency of antibiotic use points to an over-use of antimicrobials in COVID-19 patients. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Medical School and University Hospital. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal do Rio Grande do Sul. Institute for Health Technology Assessment. Porto Alegre, RS, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Medical School and University Hospital. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Medical School and University Hospital. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Center for Research and Graduate Studies in Business Administration, Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Medical School and University Hospital. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de São João del-Rey. Divinópolis, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal do Rio Grande do Sul. Institute for Health Technology Assessment. Porto Alegre, RS, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Medical School and University Hospital. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal do Rio Grande do Sul. Institute for Health Technology Assessment. Porto Alegre, RS, Brazil | pt_BR |
Affilliation | Vall d’Hebron University Hospital, PROSICS Barcelona. Barcelona, Spain / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal do Rio Grande do Sul. Institute for Health Technology Assessment. Porto Alegre, RS, Brazil. | pt_BR |
Subject | COVID-19 | pt_BR |
Subject | SARS-CoV-2 | pt_BR |
Subject | Hospitalizations | pt_BR |
Subject | Pandemic | pt_BR |
Subject | Mortalidade | pt_BR |
Subject | Doenças progressivas | pt_BR |