Use este identificador para citar ou linkar para este item:
https://www.arca.fiocruz.br/handle/icict/46117
Tipo de documento
ArtigoDireito Autoral
Acesso restrito
Data de embargo
2023
Coleções
- IOC - Artigos de Periódicos [12500]
Metadata
Mostrar registro completo
INFLUENCE OF PURINERGIC SIGNALING ON GLUCOSE TRANSPORTERS: A POSSIBLE MECHANISM AGAINST INSULIN RESISTANCE?
Diabetes tipo 2
Sinalização purinérgica
Insulin resistance
Inflamação
Afiliação
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxoplasmose e Outras Protozoases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxoplasmose e Outras Protozoases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxoplasmose e Outras Protozoases. Rio de Janeiro, RJ, Brasil.
Resumo em Inglês
Metabolic disorders, such as insulin resistance, affect many people worldwide due to the prevalence of obesity
and type 2 diabetes, which are pathologies that impair glycemic metabolism. Glucose is the primary energetic
substrate of the body and is essential for cellular function. As the cell membrane is not permeable to glucose
molecules, there are two distinct groups of glucose transporters: sodium-glucose-linked transporters (SGLTs) and
the glucose transporter (GLUT) family. These transporters facilitate the entry of glucose into the bloodstream or
cytoplasm where it functions in the production of adenosine 5 ́-triphosphate (ATP). This nucleotide acts in
several cellular mechanisms, such as protein phosphorylation and cellular immune processes. ATP directly and
indirectly acts as an agonist for purinergic receptors in high concentrations in the extracellular environment.
Composed by P1 and P2 groups, the purinoreceptors cover several cellular mechanisms involving cytokines,
tumors, and metabolic signaling pathways. Previous publications have indicated that the purinergic signaling
activity in insulin resistance and glucose transporters modulates relevant actions on the deregulations that can
affect glycemic homeostasis. Thus, this review focuses on the pharmacological influence of purinergic signaling
on the modulation of glucose transporters, aiming for a new way to combat insulin resistance and other metabolic
disorders.
Palavras-chave
Transportadores de glicoseDiabetes tipo 2
Sinalização purinérgica
Insulin resistance
Inflamação
Compartilhar