Author | Vinhaes, Caian L. | |
Author | Pereira, Mariana Araujo | |
Author | Tibúrcio, Rafael | |
Author | Cubillos-Angulo, Juan Manuel | |
Author | Demitto, Fernanda O. | |
Author | Akrami, Kevan M. | |
Author | Andrade, Bruno de Bezerril | |
Access date | 2021-03-04T12:03:06Z | |
Available date | 2021-03-04T12:03:06Z | |
Document date | 2021 | |
Citation | VINHAES, Caian L. et al. Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIV. Life, v. 11, 2021. | pt_BR |
ISSN | 2075-1729 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/46252 | |
Sponsorship | Intramural Research Program of the Fundação Oswaldo
Cruz, Brazil. The work of Caian Vinhes was supported by MONSTER Initiative and Conselho
Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. Mariana Araújo-Pereira,
Rafael Tibúrcio and Juan Cubillos-Angulo were supported by the Coordenação de Aperfeiçoamento
de Pessoal de Nível Superior (PhD fellowship. Finance code 001). Bruno Andrade is a senior fellow
from CNPq and was also supported by the National Institutes of Allergy and Infectious Diseases,
USA (U01-AI115940). | pt_BR |
Language | eng | pt_BR |
Publisher | MDPI | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Inflamação | pt_BR |
Subject in Portuguese | Mortalidade | pt_BR |
Subject in Portuguese | HIV | pt_BR |
Subject in Portuguese | Síndrome Inflamatória da Reconstituição Imune | pt_BR |
Title | Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIV | pt_BR |
Type | Article | pt_BR |
DOI | 10.3390/life11010065 | |
Abstract | Antiretroviral therapy (ART) has represented a major advancement in the care of people
living with HIV (PLWHH), resulting in significant reductions in morbidity and mortality through immune
reconstitution and attenuation of homeostatic disruption. Importantly, restoration of immune
function in PLWH with opportunistic infections occasionally leads to an intense and uncontrolled
cytokine storm following ART initiation known as immune reconstitution inflammatory syndrome
(IRIS). IRIS occurrence is associated with the severe and rapid clinical deterioration that results in
significant morbidity and mortality. Here, we detail the determinants underlying IRIS development
in PLWH, compiling the available knowledge in the field to highlight details of the inflammatory
responses in IRIS associated with the most commonly reported opportunistic pathogens. This review
also highlights gaps in the understanding of IRIS pathogenesis and summarizes therapeutic strategies
that have been used for IRIS. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Bahia Foundation for the Development of Sciences. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil. | pt_BR |
Affilliation | Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil . | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil / University of California. Department of Medicine. Divisions of Infectious Diseases and Pulmonary, Critical Care and Sleep Medicine. San Diego, CA, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Bahia Foundation for the Development of Sciences. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil / Centro Universitário Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brazil. | pt_BR |
Subject | Systemic inflammation | pt_BR |
Subject | Mycobacteria | pt_BR |
Subject | HIV | pt_BR |
Subject | Immune reconstitution inflammatory syndrome (IRIS) | pt_BR |