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Autor | Rimolo, Lorena dos Santos Marreto | |
Autor | Saraiva, Roberto Magalhães | |
Autor | Cunha, Ademir Batista da | |
Fecha de acceso | 2021-03-08T23:03:16Z | |
Fecha de disponibilización | 2021-03-08T23:03:16Z | |
Fecha de publicación | 2020 | |
ISSN | 2359-4802 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/46311 | |
Idioma | eng | pt_BR |
Editor | Scielo | pt_BR |
Derechos de autor | open access | pt_BR |
Título | Evaluation of the Autonomic Nervous System in Chronic Chagasic Cardiopathy: A Systematic Review of the Literature | pt_BR |
Tipo del documento | Article | pt_BR |
DOI | 10.36660/ijcs.20190122 | |
Resumen en Inglés | Background: The importance of regional sympathetic denervation in the pathophysiology and prognosis of Chagas disease has been recognized. Objective: To conduct a review of studies that have assessed dysautonomia in chronic Chagas heart disease. Methods: The search was performed on the Medline, Pubmed, Lilacs and SciELO databases. The inclusion criteria were: original articles published in full; studies on individuals with Chagas disease, that used diagnostic methods for chagasic cardiomyopathy, and had clear inclusion and exclusion criteria. Duplicate studies, studies including children (0 to 10 years old), studies involving animals, in vitro experiments, case reports, editorials, theses, and dissertations were excluded. Results: A total of 281 articles were retrieved, and 10 met the inclusion criteria and were analyzed. There was great heterogeneity as to the technique for assessing dysautonomia, groups of patients studied and classification of Chagas disease. The methods used for studying the autonomic system was immunohistochemistry (n=1), Valsalva and tilt-test (n=1), scintigraphy (n=6) and Holter monitoring (n=2). The results indicated dysautonomia in the indeterminate, digestive and cardiac forms of Chagas disease, and sympathetic denervation in the indeterminate and cardiac forms of the disease. There was agreement between areas of denervation, hypoperfusion and fibrosis, but areas of denervation were larger than those of hypoperfusion. The frequency of denervation and its extension increased from the indeterminate to the cardiac form. There was an association between extension of denervation and previous history of malignant ventricular arrhythmia. Conclusions: The evidence presented in this review supports that an early diagnosis of autonomic denervation in chronic Chagas' disease allows the identification of patients with an increased risk of sudden death. | pt_BR |
Afiliación | Hospital Universitário Antônio Pedro. Niterói, RJ, Brasil. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Afiliación | Hospital Universitário Antônio Pedro. Niterói, RJ, Brasil. | pt_BR |
Palavras clave en Inglês | Chagas Disease | pt_BR |
Palavras clave en Inglês | Chagas Cardiomyopathy | pt_BR |
Palavras clave en Inglês | Arrhythmias, Cardiac | pt_BR |
Palavras clave en Inglês | Primary Dysautonomias | pt_BR |
Palavras clave en Inglês | Autonomic Nervous System | pt_BR |
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INI - Artigos de Periódicos [3397]