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https://www.arca.fiocruz.br/handle/icict/47270
SARS‑COV‑2 GENOMIC SURVEILLANCE IN RONDÔNIA, BRAZILIAN WESTERN AMAZON
Author
Botelho-Souza, Luan Felipo
Lima, Felipe Souza Nogueira
Roca, Tárcio Peixoto
Naveca, Felipe Gomes
Santos, Alcione de Oliveria dos
Maia, Adriana Cristina Salvador
Silva, Cicileia Correia da
Mendonça, Aline Linhares Ferreira de Melo
Lugtenburg, Celina Aparecida Bertoni
Azzi, Camila Flávia Gomes
Fontes, Juliana Loca Furtado
Cavalcante, Suelen
Rampazzo, Rita de Cássia Pontello
Santos, Caio Henrique Nemeth
Guimarães, Alice Paula Di Sabatino
Máximo, Fernando Rodrigues
Salcedo, Juan Miguel Villalobos
Vieira, Deusilene Souza
Lima, Felipe Souza Nogueira
Roca, Tárcio Peixoto
Naveca, Felipe Gomes
Santos, Alcione de Oliveria dos
Maia, Adriana Cristina Salvador
Silva, Cicileia Correia da
Mendonça, Aline Linhares Ferreira de Melo
Lugtenburg, Celina Aparecida Bertoni
Azzi, Camila Flávia Gomes
Fontes, Juliana Loca Furtado
Cavalcante, Suelen
Rampazzo, Rita de Cássia Pontello
Santos, Caio Henrique Nemeth
Guimarães, Alice Paula Di Sabatino
Máximo, Fernando Rodrigues
Salcedo, Juan Miguel Villalobos
Vieira, Deusilene Souza
Affilliation
Fundação Oswaldo Cruz. Porto Velho, RO, Brasil / Rondônia Central Public Health Laboratory. Porto Velho, RO, Brasil.
Fundação Oswaldo Cruz. Porto Velho, RO, Brasil / Federal University of Rondônia. Postgraduate Program in Experimental Biology. Porto Velho, RO, Brasil.
Fundação Oswaldo Cruz. Porto Velho, RO, Brasil / Federal University of Rondônia. Postgraduate Program in Experimental Biology. Porto Velho, RO, Brasil.
Fundação Oswaldo Cruz. Leônidas and Maria Deane Institute. Manaus, AM, Brasil.
Fundação Oswaldo Cruz. Porto Velho, RO, Brasil / Rondônia Central Public Health Laboratory. Porto Velho, RO, Brasil.
Rondônia State Government. State Health Secretariat. Porto Velho, RO, Brasil.
Rondônia State Government. State Health Secretariat. Porto Velho, RO, Brasil.
Rondônia State Government. State Health Secretariat. Porto Velho, RO, Brasil.
Rondônia Central Public Health Laboratory. Porto Velho, RO, Brasil / Rondônia State Government, State Health Secretariat. Porto Velho, RO, Brasil.
Rondônia State Government. State Health Secretariat. Porto Velho, RO, Brasil.
Rondônia Central Public Health Laboratory. Porto Velho, RO, Brasil / Rondônia State Government, State Health Secretariat. Porto Velho, RO, Brasil.
Rondônia Central Public Health Laboratory. Porto Velho, RO, Brasil / Rondônia State Government, State Health Secretariat. Porto Velho, RO, Brasil.
Institute of Molecular Biology of Paraná. Curitiba, PR, Brasil.
Rondônia State Government. State Health Secretariat. Porto Velho, RO, Brasil.
Fundação Oswaldo Cruz. Porto Velho, RO, Brasil.
Rondônia State Government. State Health Secretariat. Porto Velho, RO, Brasil.
Fundação Oswaldo Cruz. Porto Velho, RO, Brasil / Tropical Medicine Research Center of Rondônia. Porto Velho, RO, Brasil.
Fundação Oswaldo Cruz. Porto Velho, RO, Brasil / Tropical Medicine Research Center of Rondônia. Porto Velho, RO, Brasil.
Fundação Oswaldo Cruz. Porto Velho, RO, Brasil / Federal University of Rondônia. Postgraduate Program in Experimental Biology. Porto Velho, RO, Brasil.
Fundação Oswaldo Cruz. Porto Velho, RO, Brasil / Federal University of Rondônia. Postgraduate Program in Experimental Biology. Porto Velho, RO, Brasil.
Fundação Oswaldo Cruz. Leônidas and Maria Deane Institute. Manaus, AM, Brasil.
Fundação Oswaldo Cruz. Porto Velho, RO, Brasil / Rondônia Central Public Health Laboratory. Porto Velho, RO, Brasil.
Rondônia State Government. State Health Secretariat. Porto Velho, RO, Brasil.
Rondônia State Government. State Health Secretariat. Porto Velho, RO, Brasil.
Rondônia State Government. State Health Secretariat. Porto Velho, RO, Brasil.
Rondônia Central Public Health Laboratory. Porto Velho, RO, Brasil / Rondônia State Government, State Health Secretariat. Porto Velho, RO, Brasil.
Rondônia State Government. State Health Secretariat. Porto Velho, RO, Brasil.
Rondônia Central Public Health Laboratory. Porto Velho, RO, Brasil / Rondônia State Government, State Health Secretariat. Porto Velho, RO, Brasil.
Rondônia Central Public Health Laboratory. Porto Velho, RO, Brasil / Rondônia State Government, State Health Secretariat. Porto Velho, RO, Brasil.
Institute of Molecular Biology of Paraná. Curitiba, PR, Brasil.
Rondônia State Government. State Health Secretariat. Porto Velho, RO, Brasil.
Fundação Oswaldo Cruz. Porto Velho, RO, Brasil.
Rondônia State Government. State Health Secretariat. Porto Velho, RO, Brasil.
Fundação Oswaldo Cruz. Porto Velho, RO, Brasil / Tropical Medicine Research Center of Rondônia. Porto Velho, RO, Brasil.
Fundação Oswaldo Cruz. Porto Velho, RO, Brasil / Tropical Medicine Research Center of Rondônia. Porto Velho, RO, Brasil.
Abstract
SARS-CoV-2 has spread rapidly around the world, with Brazil currently considered an epicenter of the pandemic. The Northern region has the second highest incidence coefficient, as well as the third highest mortality rate in the country. This study aimed to investigate information about the evolutionary history of epidemic spread and genetic aspects of strains isolated on the Western Amazon, in the State of Rondônia, Brazil. It was possible to detect a total of 22 mutations. Some of these alterations may possibly be related to effects on transmissibility, the fidelity of RNA replication, the ability of cancer patients to respond to infection, beyond a mutation that emerged after the introduction of SARS-CoV-2 in Rondônia. At least two events of introduction were detected, corresponding to the B.1 and B.1.1 European lineages. An introduction was observed possibly through Argentina, where strains originated that circulated in the Minas Gerais and Ceará Brazilian states, prior to Rondônia (B.1.), as well as through the Minas Gerais state and the Federal District, which gave rise to strains that spread to Rondônia, from the capital to more rural parts of the state (B.1.1.). The findings show the need to monitor the genetic epidemiology of COVID-19, in order to surveil the virus’s evolution, dispersion and diversity.
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