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LUTZOMYIA LONGIPALPIS ANTIMICROBIAL PEPTIDES: DIFFERENTIAL EXPRESSION DURING DEVELOPMENT AND POTENTIAL INVOLVEMENT IN VECTOR INTERACTION WITH MICROBIOTA AND LEISHMANIA
Peptídeos antimicrobianos
Imunidade inata
Silenciamento genético RNAi
Leishmania
Microbiota
Antimicrobial peptides
Innate immunity
RNAi gene silencing
Leishmania
Microbiota
Autor
Afiliación
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil / Department of Parasitology. Faculty of Science. Charles University. Prague, Czech Republic.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil.
Department of Parasitology. Faculty of Science. Charles University. Prague, Czech Republic.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil.
Department of Parasitology. Faculty of Science. Charles University. Prague, Czech Republic.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil.
Department of Parasitology. Faculty of Science. Charles University. Prague, Czech Republic.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil.
Department of Parasitology. Faculty of Science. Charles University. Prague, Czech Republic.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil.
Resumen en ingles
Antimicrobial peptides (AMPs) are produced to control bacteria, fungi, protozoa, and
other infectious agents. Sand fly larvae develop and feed on a microbe-rich substrate, and the
hematophagous females are exposed to additional pathogens. We focused on understanding the
role of the AMPs attacin (Att), cecropin (Cec), and four defensins (Def1, Def2, Def3, and Def4)
in Lutzomyia longipalpis, the main vector of visceral leishmaniasis in the Americas. Larvae and
adults were collected under different feeding regimens, in addition to females artificially infected by
Leishmania infantum. AMPs’ gene expression was assessed by qPCR, and gene function of Att and Def2
was investigated by gene silencing. The gene knockdown effect on bacteria and parasite abundance
was evaluated by qPCR, and parasite development was verified by light microscopy. We demonstrate
that L. longipalpis larvae and adults trigger AMPs expression during feeding, which corresponds to
an abundant presence of bacteria. Att and Def2 expression were significantly increased in Leishmania infected females, while Att suppression favored bacteria growth. In conclusion, L. longipalpis AMPs’
expression is tuned in response to bacteria and parasites but does not seem to interfere with the
Leishmania cycle.
Palabras clave en portugues
Lutzomyia longipalpisPeptídeos antimicrobianos
Imunidade inata
Silenciamento genético RNAi
Leishmania
Microbiota
Palabras clave en ingles
Lutzomyia longipalpisAntimicrobial peptides
Innate immunity
RNAi gene silencing
Leishmania
Microbiota
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