Author | Lima, Maiara N. | |
Author | Freitas, Rodrigo J. R. X. | |
Author | Passos, Beatriz A. B. R. | |
Author | Darze, Ana Maria G. | |
Author | Faria Neto, Hugo C. Castro | |
Author | Maron-Gutierrez, Tatiana | |
Access date | 2021-07-16T14:52:33Z | |
Available date | 2021-07-16T14:52:33Z | |
Document date | 2021 | |
Citation | LIMA, Maiara N. et al. Neurovascular Interactions in Malaria. Neuroimmunomodulation, 7 p, May 2021. | pt_BR |
ISSN | 1021-7401 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/48260 | |
Language | eng | pt_BR |
Publisher | Karger Publishers | pt_BR |
Rights | open access | |
Subject in Portuguese | Malaria | pt_BR |
Subject in Portuguese | Barreira hematoencefalica | pt_BR |
Subject in Portuguese | Células endoteliais | pt_BR |
Subject in Portuguese | Microglia | pt_BR |
Subject in Portuguese | Astrócitos | pt_BR |
Subject in Portuguese | Neurônios | pt_BR |
Title | Neurovascular Interactions in Malaria | pt_BR |
Type | Article | |
DOI | 10.1159/000515557 | |
Abstract | Malaria is caused by Plasmodium infection and remains a se rious public health problem worldwide, despite control ef forts. Malaria can progress to severe forms, affecting multi ple organs, including the brain causing cerebral malaria (CM). CM is the most severe neurological complication of malaria, and cognitive and behavior deficits are commonly reported in surviving patients. The number of deaths from
malaria has been reducing in recent years, and as a conse quence, neurological sequelae have been more evident. Neurological damage in malaria might be related to the neu roinflammation, characterized by glia cell activation, neuro nal apoptosis and changes in the blood-brain barrier (BBB) integrity. The neurovascular unit (NVU) is responsible for maintaining the homeostasis of the BBB. Endothelial and pericytes cells in the cerebral microvasculature and neural cells, as astrocytes, neurons, and microglia, compose the
NVU. The NVU can be disturbed by parasite metabolic prod ucts, such as heme and hemozoin, or cytokines that can promote activation of endothelial and glial cells and lead to in creased BBB permeability and subsequently neurodegener ation. In this review, we will approach the main changes that
happen in the cells of the NVU due to neuroinflammation
caused by malaria infection, and elucidate how the systemic
pathophysiology is involved in the onset and progression of
CM. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Malaria | pt_BR |
Subject | Blood-brain barrier | pt_BR |
Subject | Endothelial cells | pt_BR |
Subject | Microglia | pt_BR |
Subject | Astrocytes | pt_BR |
Subject | Neurons | pt_BR |