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https://www.arca.fiocruz.br/handle/icict/48837
Tipo
PreprintDerechos de autor
Acceso restringido
Fecha del embargo
2023
Colecciones
- IOC - Preprint [117]
Metadatos
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THE INFLAMMATORY CYTOKINE PROFILE ASSOCIATED WITH LIVER DAMAGE IS BROADER AND STRONGER IN CHRONIC HEPATITIS B PATIENTS COMPARED TO ACUTE HEPATITIS B PATIENTS.
Citocinas
Inflamação
Biomarcador
Hepatite B
Paciente
Plasma
Quimiocinas
Cytokines
Biomarker
Hepatitis B
Patient
Plasma
Chemokines
Inflammation
Autor
Valiente, Alexandra Johnson
Liem, Kin Seng
Schwarz, Kathleen B.
Rosenthal, Philip
Murray, Karen F.
Mogul, Douglas
Teckman, Jeffery
Rodriguez-Baez, Norberto
Schwarzenberg, Sarah Jane
Feld, Jordan J.
Wong, David K.
Lewis-Ximenez, Lia L.
Lauer, Georg
Hansen, Bettina E.
C. Ling, Simon
Janssen, Harry L.A.
Gehring, Adam J.
Liem, Kin Seng
Schwarz, Kathleen B.
Rosenthal, Philip
Murray, Karen F.
Mogul, Douglas
Teckman, Jeffery
Rodriguez-Baez, Norberto
Schwarzenberg, Sarah Jane
Feld, Jordan J.
Wong, David K.
Lewis-Ximenez, Lia L.
Lauer, Georg
Hansen, Bettina E.
C. Ling, Simon
Janssen, Harry L.A.
Gehring, Adam J.
Afiliación
Department of Immunology, University of Toronto. Ontario, Canada / Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network. Toronto, Ontario Canada.
Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network. Toronto, Ontario Canada / Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam. Rotterdam, The Netherlands.
Division of Pediatric Gastroenterology, University of California San Diego. San Diego, California, USA / Department of Pediatrics, Johns Hopkins University. Baltimore, Maryland, USA.
Department of Pediatrics, University of California. San Francisco, San Francisco, California, USA.
Seattle Children's Hospital, Seattle. Washington, USA.
Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland, USA,
Department of Pediatrics, Saint Louis University. St. Louis, Missouri, USA.
Department of Pediatrics, University of Texas Southwestern, Dallas, Texas, USA,
Department of Pediatrics, University of Minnesota. Minneapolis, Minnesota, USA.
Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network. Toronto, Ontario Canada / Institute of Medical Science, University of Toronto. Ontario, Canada.
Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network. Toronto, Ontario Canada.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.
Massachusetts General Hospital. Boston, Massachusetts, USA.
Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network. Toronto, Ontario Canada / Institute of Health Policy, Management and Evaluation, University of Toronto. Toronto, Ontario, Canada.
Division of Gastroenterology, Hepatology & Nutrition, the Hospital for Sick Children. Toronto, Ontario, Canada / Department of Paediatrics, University of Toronto. Toronto, Ontario, Canada.
Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network. Toronto, Ontario Canada / Institute of Medical Science, University of Toronto. Ontario, Canada.
Department of Immunology, University of Toronto. Ontario, Canada / Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network. Toronto, Ontario Canada / Institute of Medical Science, University of Toronto. Ontario, Canada.
Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network. Toronto, Ontario Canada / Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam. Rotterdam, The Netherlands.
Division of Pediatric Gastroenterology, University of California San Diego. San Diego, California, USA / Department of Pediatrics, Johns Hopkins University. Baltimore, Maryland, USA.
Department of Pediatrics, University of California. San Francisco, San Francisco, California, USA.
Seattle Children's Hospital, Seattle. Washington, USA.
Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland, USA,
Department of Pediatrics, Saint Louis University. St. Louis, Missouri, USA.
Department of Pediatrics, University of Texas Southwestern, Dallas, Texas, USA,
Department of Pediatrics, University of Minnesota. Minneapolis, Minnesota, USA.
Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network. Toronto, Ontario Canada / Institute of Medical Science, University of Toronto. Ontario, Canada.
Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network. Toronto, Ontario Canada.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.
Massachusetts General Hospital. Boston, Massachusetts, USA.
Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network. Toronto, Ontario Canada / Institute of Health Policy, Management and Evaluation, University of Toronto. Toronto, Ontario, Canada.
Division of Gastroenterology, Hepatology & Nutrition, the Hospital for Sick Children. Toronto, Ontario, Canada / Department of Paediatrics, University of Toronto. Toronto, Ontario, Canada.
Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network. Toronto, Ontario Canada / Institute of Medical Science, University of Toronto. Ontario, Canada.
Department of Immunology, University of Toronto. Ontario, Canada / Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network. Toronto, Ontario Canada / Institute of Medical Science, University of Toronto. Ontario, Canada.
Resumen en ingles
Liver damage in hepatitis B is immune driven and correlates with inflammatory markers in patient
serum. There is no comparison of these markers to determine if inflammatory profiles are distinct to
different types of liver damage across patients at different stages of disease. We measured 25
inflammatory markers in acute hepatitis B, chronic hepatitis B patients with HBeAg seroconversion
and chronic patients stopping nucleoside analogue therapy. Myeloid markers dominated the
inflammatory profile in all stages of hepatitis B. More inflammatory markers were detectable in
chronic patients, including elevated concentrations of cytotoxic effectors Fas ligand, TRAIL and TNF-a.
Palabras clave en portugues
Vírus da Hepatite BCitocinas
Inflamação
Biomarcador
Hepatite B
Paciente
Plasma
Quimiocinas
Palabras clave en ingles
Hepatitis B virusCytokines
Biomarker
Hepatitis B
Patient
Plasma
Chemokines
Inflammation
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