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https://www.arca.fiocruz.br/handle/icict/48855
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PatentCopyright
Open access
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- PR - ICC - Patentes [32]
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POLYPEPTIDE WITH ASPARAGINASE ACTIVITY, EXPRESSION CASSETTE, EXPRESSION VECTOR, HOST CELL, PHARMACEUTICAL COMPOSITION, METHODS FOR PRODUCING A POLYPEPTIDE WITH ASPARAGINASE ACTIVITY AND FOR PREVENTING OR TREATING CANCER, AND USE OF A POLYPEPTIDE
Organização Mundial para Propriedade Intelectual OMPI
Estados Unidos da América
Escritório de Patentes Europeu
Canadá
Índia
China
Alternative title
Polypeptide a activite asparaginase, cassette d'expression, vecteur d'expression, cellule hote, composition pharmaceutique, procedes pour produire un polypeptide a activite aspara ginase et pour prevenir ou traiter le cancer, et utilisation d'un polypeptideInventor(s)
Affilliation
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Applicant
Fundação Oswaldo CruzFilling number
CA3105326A1
Filling date
2020-07-16
Priority number
BR102018001033-6A2
Patent number
CA3105326A1
Abstract
The present invention relates to polypeptides with asparaginase activity, which have an increased self-processing rate in comparison to wild-type human L-asparaginase (ASRGL1), said polypeptides having a mutation in the glycine-rich loop of ASRGL1, denominated the HGG (Histidine 8-Glycine 9-Glycine 10) loop. Polynucleotides encoding the polypeptides of the invention, expression cassettes comprising said polynucleotides, expression vectors, host cells, pharmaceutical compositions, uses of the polypeptide of the invention in manufacturing a medication for preventing or treating cancer, and methods for producing the polypeptide of the invention and for preventing or treating cancer are also described herein.
Publisher
Canadian Intelectual Property Office
IPC number
A61K 38/50A61P 35/02C12N 15/66A61P 35/00C12N 15/55
Filling country
BrasilOrganização Mundial para Propriedade Intelectual OMPI
Estados Unidos da América
Escritório de Patentes Europeu
Canadá
Índia
China
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