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EXPRESSION OF VCAN AND ITS RECEPTORS IN CANINE MAMMARY CARCINOMAS WITH OR WITHOUT MYOEPITHELIAL PROLIFERATION
Células epiteliais
Matriz extracelular
Imuno-histoquímica
Anticorpos
Afiliación
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Bahia, Brasil.
Federal University of Bahia. School of Veterinary Medicine and Zootechny. Department of Pathology and Clinics. Salvador, BA, Brazil
Federal University of Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.
Federal University of Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.
Federal University of Bahia. School of Veterinary Medicine and Zootechny. Department of Pathology and Clinics. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Bahia, Brasil.
Federal University of Bahia. School of Veterinary Medicine and Zootechny. Department of Pathology and Clinics. Salvador, BA, Brazil
Federal University of Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.
Federal University of Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.
Federal University of Bahia. School of Veterinary Medicine and Zootechny. Department of Pathology and Clinics. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Bahia, Brasil.
Resumen en ingles
The proteoglycan versican (VCAN) plays a complex role in cancer. The expression of this molecule has been
related to invasion and progression in malignant mixed tumors, such as carcinoma in mixed tumors (CMT) of the
canine mammary gland. In addition, its interaction with surface cell receptors EGFR, HER-2 and CD44 in malignant
epithelial cells may be responsible for proliferation and cellular motility in early stages of cancer. We
comparatively evaluated the expression of this proteoglycan and its receptors in in situ and invasive areas of
simple carcinomas (SC) and CMT to investigate similarities and differences between these histological types.
Immunohistochemistry was performed with anti-VCAN, anti-CD44, anti-EGFR and anti-HER-2 antibodies in 32
cases of SC or CMT. VCAN was highly expressed in stroma adjacent to invasive areas in SC and CMT. CMTs
presented comparatively higher expression of VCAN in stroma adjacent to in situ and in invasive areas than in
corresponding areas in SCs. In CMT, EGFR and HER-2 expressions were higher in situ compared to invasive areas.
In contrast, increased CD44 and EGFR expression was found in invasive areas in SC compared to CMT. These
results indicate that versican expression is similarly associated with invasiveness in SC and CMT, however higher
levels were seen in CMT suggesting that the presence of myoepithelial proliferation in this tumor type participates
in stromal composition and promoting an increase in the expression of versican.
Palabras clave en portugues
CarcinomaCélulas epiteliais
Matriz extracelular
Imuno-histoquímica
Anticorpos
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