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CYTOKINE PROFLE DURING OCCULT HEPATITIS B VIRUS INFECTION IN CHRONIC HEPATITIS C PATIENTS
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Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Espirito Santo. Vitória, ES, Brasil
Universidade Federal do Estado do Rio de Janeiro. Hospital Gaffrée Guinle. Ambulatório de Doenças do Fígado. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Estado do Rio de Janeiro. Hospital Gaffrée Guinle. Ambulatório de Doenças do Fígado. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Espirito Santo. Vitória, ES, Brasil
Universidade Federal do Estado do Rio de Janeiro. Hospital Gaffrée Guinle. Ambulatório de Doenças do Fígado. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Estado do Rio de Janeiro. Hospital Gaffrée Guinle. Ambulatório de Doenças do Fígado. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Abstract
Background: The hepatitis B virus (HBV) is one of the leading causes of acute, chronic and occult hepatitis (OBI)
representing a serious public health threat. Cytokines are known to be important chemical mediators that regulate
the diferentiation, proliferation and function of immune cells. Accumulating evidence indicate that the inadequate
immune responses are responsible for HBV persistency. The aim of this study were to investigate the cytokines IFN-γ,
TNF-α, IL-2, IL-4, IL-6, IL-10 and IL-17A in patients with OBI and verify if there is an association between the levels of
these cytokines with the determination of clinical courses during HBV occult infection.
Methods: 114 patients with chronic hepatitis C were investigated through serological and molecular tests, the
OBI coinfected patients were subjected to the test for cytokines using the commercial human CBA kit. As controls,
ten healthy donors with no history of liver disease and 10 chronic HBV monoinfected patients of similar age to OBI
patients were selected.
Results: Among 114 HCV patients investigated, 11 individuals had occult hepatitis B. The levels of cytokines were
heterogeneous between the groups, most of the cytokines showed higher levels of production detection among
OBI/HCV individuals when compared to control group and HBV monoinfected pacients. We found a high level of IL 17A in the HBV monoinfected group, high levels of TNF-α, IL-10, IL-6, IL-4 and IL-2 in OBI/HCV patients.
Conclusion: These cytokines could be involved in the persistence of HBV DNA in hepatocytes triggers a constant
immune response, inducing continuous liver infammation, which can accelerate liver damage and favor the develop ment of liver cirrhosis in other chronic liver diseases.
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