Author | Cavalcante, Tamires Barradas | |
Author | Ribeiro, Marizélia Rodrigues Costa | |
Author | Sousa, Patrícia da Silva | |
Author | Costa, Elaine de Paula Fiod | |
Author | Alves, Maria Teresa Seabra Soares de Brito e | |
Author | Simões, Vanda Maria Ferreira | |
Author | Batista, Rosângela Fernandes Lucena | |
Author | Takahasi, Eliana Harumi Morioka | |
Author | Amaral, Gláucio Andrade | |
Author | Khouri, Ricardo | |
Author | Branco, Maria dos Remédios Freitas Carvalho | |
Author | Mendes, Ana Karolina Torres | |
Author | Costa, Luciana Cavalcante | |
Author | Campos, Marcos Adriano Garcia | |
Author | Silva, Antônio Augusto Moura da | |
Access date | 2021-09-20T11:27:25Z | |
Available date | 2021-09-20T11:27:25Z | |
Document date | 2021 | |
Citation | CAVALCANTE, Tamires Barradas et al. Congenital Zika syndrome: Growth, clinical, and motor development outcomes up to 36 months of age and differences according to microcephaly at birth. International Journal of Infectious Diseases, 2021. | pt_BR |
ISSN | 1201-9712 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/49113 | |
Description | a Department of Public Health, Federal University of Maranhão, São Luís, Maranhão, Brazil
b Department of Medicine III, Federal University of Maranhão, São Luís, Maranhão, Brazil
c Reference Center on Neurodevelopment, Assistance and Rehabilitation of Children/NINAR – Health Secretariat of the State of Maranhão, São Luís, Maranhão,
Brazil
d Department of Medicine I, Federal University of Maranhão, São Luís, Maranhão, Brazil
e Sarah Network of Neurorehabilitation Hospitals, São Luís, Maranhão, Brazil
f Laboratory of Vector-Borne Infectious Diseases, Gonçalo Moniz Institute, Fiocruz-Bahia, and Department of Pathology and Legal Medicine, Faculty of
Medicine, Federal University of Bahia, Salvador, Bahia, Brazil | pt_BR |
Sponsorship | Department of Science and
Technology of the Brazilian Ministry of Health, Maranhão State
Health Secretariat, National Council for Scientific and Technologi-
cal Development (CNPq is the Portuguese acronym, grant 440573/
2016-5), Coordination for the Improvement of Higher Education
Personnel (CAPES is the Portuguese acronym, grant 88881.130813/
2016-01), and the Foundation for the Support of Research and
Scientific and Technological Development of Maranhão (FAPEMA is
the Portuguese acronym, grant PPSUS-05963/16). | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Infecção por zika virus | pt_BR |
Subject in Portuguese | Microcefalia | pt_BR |
Subject in Portuguese | Crescimento | pt_BR |
Subject in Portuguese | Hidrocefalia | pt_BR |
Title | Congenital Zika syndrome: Growth, clinical, and motor development outcomes up to 36 months of age and differences according to microcephaly at birth | pt_BR |
Type | Article | pt_BR |
Abstract | Little is known regarding the developmental consequences of congenital Zika syndrome
(CZS) without microcephaly at birth. Most previously published clinical series were descriptive and they
had small sample sizes.
Study design: We conducted a cohort study to compare the growth, clinical, and motor development
outcomes for 110 children with CZS born with and without microcephaly up to their third birthday.
Ninety-three had their head circumference (HC) at birth abstracted and they did not have hypertensive
hydrocephalus at birth, where 61 were born with microcephaly and 32 without.
Results: The HC z-scores decreased steeply from birth to six months of age, i.e., from –3.77 to –6.39 among
those with microcephaly at birth and from –1.03 to –3.84 among those without. Thus, at 6 months of age,
the mean HC z-scores for children born without microcephaly were nearly the same as those for children
born with microcephaly. Children born without microcephaly were less likely to have brain damage,
ophthalmic abnormalities, and drug-resistant epilepsy, but the differences in many conditions were not
statistically significant.
Conclusions: Children born without microcephaly were only slightly less likely to present severe
neurologic impairment and to develop postnatal-onset microcephaly, and some of the original
differences between the groups tended to dissipate with age. | pt_BR |
Affilliation | “Múltipla – ver em notas” | pt_BR |
Subject | Zika virus infection | pt_BR |
Subject | Microcephaly | pt_BR |
Subject | Growth and development | pt_BR |
e-ISSN | 10.1016/j.ijid.2021.02.072 | |