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Autor | Ticona, Juan P. Aguilar | |
Autor | Nery Junior, Nivison | |
Autor | Ladines-Lim, Joseph B. | |
Autor | Gambrah, Claudia | |
Autor | Sacramento, Gielson | |
Autor | Freitas, Bruno de Paula | |
Autor | Bouzon, Joseane | |
Autor | Oliveira Filho, Jamary | |
Autor | Borja, Ana | |
Autor | Adhikarla, Haritha | |
Autor | Montoya, Magelda | |
Autor | Chin, Athena | |
Autor | WunderJunior, Elsio A. | |
Autor | Ballalai, Verena | |
Autor | Vieira, Carina | |
Autor | Belfort, Rubens | |
Autor | AlmeidaI, Antonio R. P. | |
Autor | Reis, Mitermayer Galvão dos | |
Autor | HarrisID, Eva | |
Autor | Ko, Albert Icksang | |
Autor | Costa, Federico | |
Fecha de acceso | 2021-12-10T11:26:17Z | |
Fecha de disponibilización | 2021-12-10T11:26:17Z | |
Fecha de publicación | 2021 | |
Referencia | TICONA, Juan P. Aguilar et al. Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study. PLoS Neglected Tropical Diseases, 2021. | pt_BR |
ISSN | 1935-2735 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/50277 | |
Descripción | 1 Instituto de Sau´de Coletiva, Universidade Federal da Bahia, Salvador, Brazil, 2 Instituto Gonc¸alo Moniz, Fundac¸ão Oswaldo Cruz,Ministe´ rio da Sau´de, Salvador, Brazil, 3 Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America, 4 Hospital Geral Roberto Santos (HGRS), Salvador, Brazil, 5 Faculdade de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil, 6 Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, Brazil, 7 Programa de Pòs-Graduac¸ão em Ciencias da Saude (PPgCS) Universidade Federal da Bahia, Salvador, Brazil, 8 Departamento de Fonoaudiologia. Instituto de Ciências da Sau´de. Universidade Federal da Bahia, Salvador, Brazil, 9 Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, United States of America | pt_BR |
Promoción | National Institutes of Health (NIAID R01 AI052473 (AK), R25 U01AI088752 (AK), FIC R01 TW009504 (AK), R25 TW009338 (AK), F31 AI114245 (AK), R01 AI121207 (AK), D43 TW010540 (AK), P01 AI106695 (EH) (https://www. niaid.nih.gov/), Wellcome Trust (102330/Z/13/Z https://wellcome.ac.uk/), Bahia State Research Support Foundation (FAPESB) ZIKA-FAPESB T.O. n ˚ PET0021/2016 (www.fapesb.ba.gov.br) and Coordination for the Improvement of Higher Education (CAPES) from Brazil (https://www.capes. gov.br/). | pt_BR |
Idioma | eng | pt_BR |
Editor | Public Library of Science | pt_BR |
Derechos de autor | open access | pt_BR |
Palabras clave en Portugués | Zika virus | pt_BR |
Palabras clave en Portugués | Microcefalia | pt_BR |
Palabras clave en Portugués | Anticorpos Monoclonais | pt_BR |
Palabras clave en Portugués | Anormalidades Congênitas | pt_BR |
Título | Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study | pt_BR |
Tipo del documento | Article | pt_BR |
DOI | 10.1371/journal. pntd.0009162 | |
Resumen en Inglés | The prevalence of developmental alterations associated with in-utero Zika virus (ZIKV) exposure in children is not well understood. Furthermore, estimation of the Population Attributable Fraction (PAF) of developmental alterations attributed to ZIKV has not been performed due to lack of population-based cohorts with data on symptomatic and asymptomatic ZIKV exposures and an appropriate control group. The aim of this study was to characterize neurodevelopmental outcomes of children at 11 to 32 months of age with intrauterine ZIKV exposure and estimate the PAF of alterations secondary to ZIKV exposure. Methodology/Principal findings We performed a cohort of biannual community-based prospective serosurveys in a slum community in Salvador, Brazil. We recruited women participating in our cohort, with a documented pregnancy from January 2015 to December 2016 and children born to those mothers. Children were classified as ZIKV exposed in utero (born from women with ZIKV seroconversion during pregnancy) or unexposed (born from women without ZIKV seroconversion or that seroconverted before/after pregnancy) by using an IgG monoclonal antibody blockade-of-binding (BoB). We interviewed mothers and performed anthropometric, audiometric, ophthalmological, neurologic, and neurodevelopmental evaluations of their children at 11 to 32 months of age. Among the 655 women participating in the cohort, 66 (10%) were pregnant during the study period. 46 (70%) of them completed follow-up, of whom ZIKV seroconversion occurred before, during, and after pregnancy in 25 (54%), 13 (28%), and 1 (2%), respectively. The rest of women, 7 (21.2%), did not present ZIKV seroconversion. At 11 to 32 months of life, the 13 ZIKV-exposed children had increased risk of mild cognitive delay (RR 5.1; 95%CI 1.1–24.4) compared with the 33 children unexposed, with a PAF of 53.5%. Exposed children also had increased risk of altered auditory behavior (RR 6.0; 95% CI 1.3–26.9), with a PAF of 59.5%. Conclusions A significant proportion of children exposed in utero to ZIKV developed mild cognitive delay and auditory behavioral abnormalities even in the absence of gross birth defects such as microcephaly and other neurodevelopmental domains. Furthermore, our findings suggest that over half of these abnormalities could be attributed to intrauterine ZIKV exposure. | pt_BR |
Afiliación | "Múltipla ver em Notas" | pt_BR |
Palavras clave en Inglês | Zika virus | pt_BR |
Palavras clave en Inglês | Microcephaly | pt_BR |
Palavras clave en Inglês | Antibodies, Monoclonal | pt_BR |
Palavras clave en Inglês | Congenital Abnormalities | pt_BR |