Autor | Foo, Suan-Sin | |
Autor | Cambou, Mary Catherine | |
Autor | Mok, Thalia | |
Autor | Fajardo, Viviana M. | |
Autor | Jung, Kyle L. | |
Autor | Fuller, Trevon | |
Autor | Chen, Weiqiang | |
Autor | Kerin, Tara | |
Autor | Mei, Jenny | |
Autor | Bhattacharya, Debika | |
Autor | Choi, Younho | |
Autor | Wu, Xin | |
Autor | Xia, Tian | |
Autor | Shin, Woo-Jin | |
Autor | Cranston, Jessica | |
Autor | Aldrovandi, Grace | |
Autor | Tobin, Nicole | |
Autor | Contreras, Deisy | |
Autor | Ibarrondo, Francisco J. | |
Autor | Yang, Otto | |
Autor | Yang, Shangxin | |
Autor | Garner, Omai | |
Autor | Cortado, Ruth | |
Autor | Bryson, Yvonne | |
Autor | Janzen, Carla | |
Autor | Ghosh, Shubhamoy | |
Autor | Devaskar, Sherin | |
Autor | Asilnejad, Brenda | |
Autor | Moreira, Maria Elisabeth | |
Autor | Vasconcelos, Zilton Farias Meira de | |
Autor | Soni, Priya R. | |
Autor | Gibson, L. Caroline | |
Autor | Brasil, Patricia | |
Autor | Comhair, Suzy A. A. | |
Autor | Arumugaswami, Vaithilingaraja | |
Autor | Erzurum, Serpil C. | |
Autor | Rao, Rashmi | |
Autor | Jung, Jae U. | |
Autor | Nielsen-Saines, Karin | |
Data de acesso | 2021-12-15T16:43:09Z | |
Data de disponibilização | 2021-12-15T16:43:09Z | |
Data do publicação | 2021 | |
Citação | FOO, Suan-Sin et al. The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2. Cell Reports Medicine, v. 2, n. 11, p. 1-25, Nov. 2021. | pt_BR |
ISSN | 2666-3791 | |
URI | https://www.arca.fiocruz.br/handle/icict/50451 | |
Idioma | eng | pt_BR |
Editor | Elsevier | pt_BR |
Direito Autoral | open access | pt_BR |
Título | The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2 | pt_BR |
Tipo do documento | Article | pt_BR |
DOI | 10.1016/j.xcrm.2021.100453 | |
Resumo em Inglês | While pregnancy increases the risk for severe COVID-19, the clinical and immunological implications of COVID-19 on maternal-fetal health remain unknown. Here, we present the clinical and immunological landscapes of 93 COVID-19 mothers and 45 of their SARS-CoV-2-exposed infants through comprehensive serum proteomics profiling for >1,400 cytokines of their peripheral and cord blood specimens. Prenatal SARS-CoV-2 infection triggers NF-κB-dependent proinflammatory immune activation. Pregnant women with severe COVID-19 show increased inflammation and unique IFN-λ antiviral signaling, with elevated levels of IFNL1 and IFNLR1. Furthermore, SARS-CoV-2 infection re-shapes maternal immunity at delivery, altering the expression of pregnancy complication-associated cytokines, inducing MMP7, MDK, and ESM1 and reducing BGN and CD209. Finally, COVID-19-exposed infants exhibit induction of T cell-associated cytokines (IL33, NFATC3, and CCL21), while some undergo IL-1β/IL-18/CASP1 axis-driven neonatal respiratory distress despite birth at term. Our findings demonstrate COVID-19-induced immune rewiring in both mothers and neonates, warranting long-term clinical follow-up to mitigate potential health risks. | pt_BR |
Afiliação | Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Medicine. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Division of Maternal-Fetal Medicine. Department of Obstetrics and Gynecology. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Division of Neonatology. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Afiliação | Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA. | pt_BR |
Afiliação | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Afiliação | Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Division of Maternal-Fetal Medicine. Department of Obstetrics and Gynecology. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Medicine. Los Angeles, CA, USA. | pt_BR |
Afiliação | Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA. | pt_BR |
Afiliação | Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA. | pt_BR |
Afiliação | Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA. | pt_BR |
Afiliação | Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Medicine. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Medicine. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Department of Pathology and Laboratory Medicine. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Department of Pathology and Laboratory Medicine. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Division of Maternal-Fetal Medicine. Department of Obstetrics and Gynecology. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Division of Neonatology. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Division of Neonatology. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Afiliação | Georgetown University. School of Medicine. Washington, DC, USA. | pt_BR |
Afiliação | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Afiliação | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Afiliação | Cedars-Sinai Medical Center. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Afiliação | Cedars-Sinai Medical Center. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Afiliação | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Afiliação | Cleveland Clinic. Lerner Research Institute. Respiratory Institute. Cleveland, OH, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Department of Molecular and Medical Pharmacology. Los Angeles, CA, USA. | pt_BR |
Afiliação | Cleveland Clinic. Lerner Research Institute. Respiratory Institute. Cleveland, OH, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Division of Maternal-Fetal Medicine. Department of Obstetrics and Gynecology. Los Angeles, CA, USA. | pt_BR |
Afiliação | Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA. | pt_BR |
Afiliação | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Palavras-chave em inglês | COVID-19 | pt_BR |
Palavras-chave em inglês | Exposed infants | pt_BR |
Palavras-chave em inglês | IFN-λ signaling | pt_BR |
Palavras-chave em inglês | Mother-infant pairs | pt_BR |
Palavras-chave em inglês | Pregnancy | pt_BR |
Palavras-chave em inglês | Prenatal SARS-CoV-2 infection | pt_BR |
Palavras-chave em inglês | Serum proteomics | pt_BR |
Palavras-chave em inglês | SARS-CoV-2 | |