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https://www.arca.fiocruz.br/handle/icict/50545
LOCALIZATION OF MULTIPLE QUANTITATIVE TRAIT LOCI INFLUENCING SUSCEPTIBILITY TO INFECTION WITH ASCARIS LUMBRICOIDES
Author
Affilliation
Department of Genetics.Southwest Foundation for Biomedical Research.
Department of Genetics.Southwest Foundation for Biomedical Research/Southwest National Primate Research Center. San Antonio, Texas
Department of Sociology and Gerontology. Miami University. Oxford, Ohio
Tribhuvan University Institute of Medicine Kathmandu. Nepal
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratory of Cellular and Molecular Immunology. Belo Horizonte, MG, Brazil
Department of Genetics. Southwest Foundation for Biomedical Research.
Department of Genetics.Southwest Foundation for Biomedical Research/Southwest National Primate Research Center. San Antonio, Texas
Department of Sociology and Gerontology. Miami University. Oxford, Ohio
Tribhuvan University Institute of Medicine Kathmandu. Nepal
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratory of Cellular and Molecular Immunology. Belo Horizonte, MG, Brazil
Department of Genetics. Southwest Foundation for Biomedical Research.
Abstract
A linkage-based genome scan of 1258 members of a single pedigree of the Jirel population of Nepal localized 6 potential quantitative trait loci (QTLs) influencing susceptibility to infection with Ascaris lumbricoides, the most common soil-transmitted intestinal helminth. Three QTLs exhibited genomewide significance, including QTLs on chromosomes 13 (logarithm of the odds ratio [LOD] score, 3.37; genomewide P =.013), 8 (LOD score, 3.03; genomewide P =.031), and 11 (LOD score, 3.19; genomewide P =.020). Another QTL on chromosome 1 approached significance (LOD score, 2.72; genomewide P =.067). There was suggestive evidence of linkage for 2 additional loci on chromosomes 1 and 13
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