Author | Falcão Júnior, João Oscar de Almeida | |
Author | Carvalho, Andréa Teixeira de | |
Author | Cândido, Eduardo Batista | |
Author | Lages, Elisa Lopes | |
Author | Freitas, Gustavo Ferreira | |
Author | Lamaita, Rívia Mara | |
Author | Bonfim, Lívia Paula Freire | |
Author | Salera, Rafael Borges | |
Author | Traiman, Paulo | |
Author | Silva Filho, Agnaldo Lopes da | |
Access date | 2021-12-30T12:27:57Z | |
Available date | 2021-12-30T12:27:57Z | |
Document date | 2013 | |
Citation | FALCÃO JÚNIOR, João Oscar Almeida et al. Assessment of chemokine serum levels in epithelial ovarian cancer patients. Tumori, v. 99, n. 4, p. 540-544, 2013. doi: 10.1700/1361.15108. | pt_BR |
ISSN | 0300-8916 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/50580 | |
Language | eng | pt_BR |
Publisher | Sage Publications | pt_BR |
Rights | restricted access | pt_BR |
Title | Assessment of chemokine serum levels in epithelial ovarian cancer patients | pt_BR |
Type | Article | pt_BR |
DOI | https://doi.org/10.1177/030089161309900417 | |
Abstract | Aims and background: The study was undertaken to investigate CCL2/MCP-1, CCL3/MIP-l alpha, CCL4/MIP-1 beta, CCL5/RANTES and CXCL8/IL-8 women with epithelial ovarian cancer.
Methods and study design: Sixteen patients diagnosed with epithelial ovarian cancer and 18 healthy women with no evidence of malign neoplasia (control group) aged from 23 to 89 years (mean +/- SEM, 58.7 +/- 2.3) were included. The epithelial ovarian cancer patients underwent laparotomy and debulking surgery Chemokines serum levels were measured by cytometric bead array. Statistical analysis was performed using Mann-Whitney and Kendall's tau. P <0.05 was considered statistically significant for all analyses.
Results: The tumor staging (FIGO) was classified into: I in 4 cases (25%), III in 5 cases (31.3%) and stage IV in 7 cases (43.8%). Sera chemokine dosages of CCL2 /MCP-1 and CCL4/MIP-1 beta were lower in epithelial ovarian cancer patients than in the control group (P = 0.021 and P = 0.030, respectively). No significant difference between groups was observed in the levels of CCL3/MIP-l alpha, CCL5/RANTES and CXCL8/IL-8. No association between the chemokines analyzed and tumor stage was found. The serum level of CCL4/MIP-1 beta was correlated with CA-125.
Conclusions: The study of serum levels of CCL2/MCP-1, CCL3/MIP-l alpha, CCL4/MIP-1 beta, CCL5/RANTES and CXCL8/IL-8 chemokines in epithelial ovarian cancer patients identified a down-regulation in CCL2/MCP-1 and CCL4/MIP-1 beta, which suggests that the two chemokines may play an important role in the pathophysiology of ovarian cancer. | pt_BR |
Affilliation | Department of Obstetric,Gynecology and Mastology.Botucatu Medical School, UNESP. São Paulo State University, Botucatu, SP | pt_BR |
Affilliation | Laboratory of Biomarkers and Monitoring Diagnosis. Rene Rachou Research Center.Oswaldo Cruz Foundation. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Department of Obstetrics and Gynecology. Federal University of Minas Gerais. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Department of Obstetrics, Gynecology and Mastology. Botucatu Medical School. UNESP. São Paulo State University, Botucatu, SP, Brasil | pt_BR |
Affilliation | Department of Obstetrics, Gynecology and Mastology. Botucatu Medical School. UNESP. São Paulo State University, Botucatu, SP, Brasil | pt_BR |
Affilliation | Pró-Criar Clinic of Assisted Reproduction. MaterDei Hospital. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Department of Obstetrics, Gynecology and Mastology. Botucatu Medical School. UNESP. São Paulo State University, Botucatu, SP, Brasil | pt_BR |
Affilliation | Department of Obstetrics, Gynecology and Mastology, Botucatu Medical School, UNESP - São Paulo State University, Botucatu, SP | pt_BR |
Affilliation | Department of Obstetrics, Gynecology and Mastology. Botucatu Medical School. UNESP. São Paulo State University, Botucatu, SP, Brasil/ Department of Obstetrics and Gynecology. Federal University of Minas Gerais. Belo Horizonte, MG, Brasil | pt_BR |
Subject | CA-125 | pt_BR |
Subject | chemokines | pt_BR |
Subject | cytometric | pt_BR |
Subject | bead array | pt_BR |
Subject | immune system | pt_BR |
Subject | ovarian cancer | pt_BR |