Author | Bonyek-Silva, Icaro | |
Author | Machado, Antônio Fernando Araujo | |
Author | Silva, Thiago Cerqueira | |
Author | Nunes, Sara | |
Author | Cruz, Marcio Rivison Silva | |
Author | Silva, Jessica | |
Author | Santos, Reinan Lima | |
Author | Barral, Aldina Maria do Prado | |
Author | Oliveira, Pablo Rafael Silveira | |
Author | Khouri, Antonio Ricardo | |
Author | Serezani, C. Henrique | |
Author | Brodskyn, Claudia Ida | |
Author | Caldas, Juliana Ribeiro | |
Author | Manoel, Barral Netto | |
Author | Boaventura, Viviane | |
Author | Tavares, Natalia Machado | |
Access date | 2022-01-07T21:27:42Z | |
Available date | 2022-01-07T21:27:42Z | |
Document date | 2021 | |
Citation | BONYEK-SILVA, Icaro et al. LTB4-Driven Inflammation and Increased Expression of ALOX5/ACE2 During Severe COVID-19 in Individuals With Diabetes. Diabetes, p. 1-47, 15 Jun. 2021. | pt_BR |
ISSN | 0012-1797 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/50680 | |
Language | eng | pt_BR |
Publisher | American Diabetes Association | pt_BR |
Later version | https://www.arca.fiocruz.br/handle/icict/49900 | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | COVID-19 | pt_BR |
Subject in Portuguese | Diabetes | pt_BR |
Subject in Portuguese | SARS-CoV-2 | pt_BR |
Subject in Portuguese | LTB4 | pt_BR |
Subject in Portuguese | ACE2 | pt_BR |
Title | LTB4-driven inflammation and increased expression of ALOX5/ACE2 during severe COVID-19 in individuals with diabetes (Preprint) | pt_BR |
Type | Preprint | pt_BR |
Abstract | Diabetes is a known risk factor for severe COVID-19, the disease caused by the new coronavirus SARS-CoV-2. However, there is a lack of knowledge about the mechanisms involved in the evolution of COVID-19 in individuals with diabetes. Therefore, we aimed to evaluate whether the chronic low-grade inflammation of diabetes could play a role in the development of severe COVID-19. We collected clinical data and blood samples of hospitalized patients for COVID-19, with diabetes and without diabetes. Plasma samples were used to measure inflammatory mediators and peripheral blood mononuclear cells, for gene expression analysis of SARS-CoV-2 main receptor system (ACE2/TMPRSS2) and main molecule of LTB4 pathway (ALOX5). We found that diabetes activates LTB4 pathway, and during COVID-19, it increases ACE2/TMPRSS2 as well as ALOX5 expression. Diabetes was also associated with COVID-19-related disorders, such as reduced SpO2/FiO2 and PaO2/FiO2 levels, and increased disease duration. In addition, the expression of ACE2 and ALOX5 are positively correlated, with increased expression in COVID-19 patients with diabetes requiring intensive care assistance. We confirmed these molecular results at the protein level, where plasma LTB4 is significantly increased in individuals with diabetes. Besides, IL-6 serum levels are increased only in individuals with diabetes requiring intensive care assistance. Together, these results indicate that LTB4 and IL-6 systemic levels, as well as, ACE2/ALOX5 blood expression could be early markers of severe COVID-19 in individuals with diabetes. | pt_BR |
Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil / Federal University of Bahia. Medical School. Salvador, BA, Brazil. | pt_BR |
Affilliation | Salvador University. Salvador, BA, Brazil. | pt_BR |
Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil / Federal University of Bahia. Medical School. Salvador, BA, Brazil. | pt_BR |
Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil / Federal University of Bahia. Medical School. Salvador, BA, Brazil. | pt_BR |
Affilliation | Salvador University. Salvador, BA, Brazil / Ernesto Simões Filho Hospital. Critical Care Unit. Salvador, BA, Brazil. Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil / Federal University of Bahia. Medical School. Salvador, BA, Brazil. | pt_BR |
Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil / Federal University of Bahia. Pharmacy School. Salvador, BA, Brazil. | pt_BR |
Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil / Federal University of Bahia. Medical School. Salvador, BA, Brazil / National Institute of Science and Technology. Institute of Investigation in Immunology. São Paulo, SP, Brazil. | pt_BR |
Affilliation | Federal University of Bahia. Institute of Biological Sciences. Salvador, BA, Brazil. | pt_BR |
Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil / Federal University of Bahia. Medical School. Salvador, BA, Brazil. | pt_BR |
Affilliation | Vanderbilt University. Department of Medicine. Division of Infectious Diseases. Medical Center. Nashville, TN, USA. | pt_BR |
Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil / Federal University of Bahia. Medical School. Salvador, BA, Brazil / National Institute of Science and Technology. Institute of Investigation in Immunology. São Paulo, SP, Brazil. | pt_BR |
Affilliation | Salvador University. Salvador, BA, Brazil / Ernesto Simões Filho Hospital. Critical Care Unit. Salvador, BA, Brazil / São Rafael Hospital–Rede d’Or. Critical Care Unit. Salvador, BA, Brazil / Bahiana School of Medicine and Public Health. Salvador, BA, Brazil. | pt_BR |
Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil / Federal University of Bahia. Medical School. Salvador, BA, Brazil / National Institute of Science and Technology. Institute of Investigation in Immunology. São Paulo, SP, Brazil. | pt_BR |
Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil / Federal University of Bahia. Medical School. Salvador, BA, Brazil. | pt_BR |
Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil / Federal University of Bahia. Medical School. Salvador, BA, Brazil / National Institute of Science and Technology. Institute of Investigation in Immunology. São Paulo, SP, Brazil. | pt_BR |
Subject | COVID-19 | pt_BR |
Subject | Diabetes | pt_BR |
Subject | Lipid mediators | pt_BR |
Subject | LTB4 | pt_BR |
Subject | ACE2 | pt_BR |
Subject | SARS-CoV-2 | pt_BR |