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SARS-COV-2 INFECTIONS AND VIRAL ISOLATIONS AMONG SERIALLY TESTED CATS AND DOGS IN HOUSEHOLDS WITH INFECTED OWNERS IN TEXAS, USA
Gatos
Cães
Zoonose reversa
Isolamento de vírus
Anticorpos neutralizantes
COVID-19
Author
Hamer, Sarah A.
Corrêa, Alex Pauvolid
Zecca, Italo B.
Davila, Edward
Auckland, Lisa A.
Roundy, Christopher M.
Tang, Wendy
Torchetti, Mia Kim
Killian, Mary Lea
Jenkins-Moore, Melinda
Mozingo, Katie
Akpalu, Yao
Ghai, Ria R.
Spengler, Jessica R.
Behravesh, Casey Barton
Fischer, Rebecca S. B.
Hamer, Gabriel L.
Corrêa, Alex Pauvolid
Zecca, Italo B.
Davila, Edward
Auckland, Lisa A.
Roundy, Christopher M.
Tang, Wendy
Torchetti, Mia Kim
Killian, Mary Lea
Jenkins-Moore, Melinda
Mozingo, Katie
Akpalu, Yao
Ghai, Ria R.
Spengler, Jessica R.
Behravesh, Casey Barton
Fischer, Rebecca S. B.
Hamer, Gabriel L.
Affilliation
College of Veterinary Medicine and Biomedical Sciences, Texas A&M University. College Station, TX 77843, USA.
College of Veterinary Medicine and Biomedical Sciences, Texas A&M University. College Station, TX 77843, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo / Fundação Oswaldo Cruz. Laboratório de Referência Nacional e Regional de SARS-CoV-2 - Laboratório de Referência nas Américas (OPAS/OMS). Rio de Janeiro, RJ, Brasil.
College of Veterinary Medicine and Biomedical Sciences, Texas A&M University. College Station, TX 77843, USA.
College of Veterinary Medicine and Biomedical Sciences, Texas A&M University. College Station, TX 77843, USA.
College of Veterinary Medicine and Biomedical Sciences, Texas A&M University. College Station, TX 77843, USA.
Department of Entomology, Texas A&M University and AgriLife Research. College Station, TX 77843, USA.
Department of Entomology, Texas A&M University and AgriLife Research. College Station, TX 77843, USA.
National Veterinary Services Laboratories, USDA APHIS VS. Ames, IA 50010, USA.
National Veterinary Services Laboratories, USDA APHIS VS. Ames, IA 50010, USA.
National Veterinary Services Laboratories, USDA APHIS VS. Ames, IA 50010, USA.
National Veterinary Services Laboratories, USDA APHIS VS. Ames, IA 50010, USA.
Brazos County Health Department. Bryan, TX 77803, USA.
National Center for Emerging and Zoonotic Infectious Diseases, U.S. Centers for Disease Control and Prevention. Atlanta, GA 30329, USA.
National Center for Emerging and Zoonotic Infectious Diseases, U.S. Centers for Disease Control and Prevention. Atlanta, GA 30329, USA.
National Center for Emerging and Zoonotic Infectious Diseases, U.S. Centers for Disease Control and Prevention. Atlanta, GA 30329, USA.
School of Public Health, Texas A&M University. College Station, TX 77843, USA.
Department of Entomology, Texas A&M University and AgriLife Research. College Station, TX 77843, USA.
College of Veterinary Medicine and Biomedical Sciences, Texas A&M University. College Station, TX 77843, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo / Fundação Oswaldo Cruz. Laboratório de Referência Nacional e Regional de SARS-CoV-2 - Laboratório de Referência nas Américas (OPAS/OMS). Rio de Janeiro, RJ, Brasil.
College of Veterinary Medicine and Biomedical Sciences, Texas A&M University. College Station, TX 77843, USA.
College of Veterinary Medicine and Biomedical Sciences, Texas A&M University. College Station, TX 77843, USA.
College of Veterinary Medicine and Biomedical Sciences, Texas A&M University. College Station, TX 77843, USA.
Department of Entomology, Texas A&M University and AgriLife Research. College Station, TX 77843, USA.
Department of Entomology, Texas A&M University and AgriLife Research. College Station, TX 77843, USA.
National Veterinary Services Laboratories, USDA APHIS VS. Ames, IA 50010, USA.
National Veterinary Services Laboratories, USDA APHIS VS. Ames, IA 50010, USA.
National Veterinary Services Laboratories, USDA APHIS VS. Ames, IA 50010, USA.
National Veterinary Services Laboratories, USDA APHIS VS. Ames, IA 50010, USA.
Brazos County Health Department. Bryan, TX 77803, USA.
National Center for Emerging and Zoonotic Infectious Diseases, U.S. Centers for Disease Control and Prevention. Atlanta, GA 30329, USA.
National Center for Emerging and Zoonotic Infectious Diseases, U.S. Centers for Disease Control and Prevention. Atlanta, GA 30329, USA.
National Center for Emerging and Zoonotic Infectious Diseases, U.S. Centers for Disease Control and Prevention. Atlanta, GA 30329, USA.
School of Public Health, Texas A&M University. College Station, TX 77843, USA.
Department of Entomology, Texas A&M University and AgriLife Research. College Station, TX 77843, USA.
Abstract
Understanding the ecological and epidemiological roles of pets in the transmission of
SARS-CoV-2 is critical for animal and human health, identifying household reservoirs, and predicting
the potential enzootic maintenance of the virus. We conducted a longitudinal household transmission
study of 76 dogs and cats living with at least one SARS-CoV-2-infected human in Texas and found
that 17 pets from 25.6% of 39 households met the national case definition for SARS-CoV-2 infections
in animals. This includes three out of seventeen (17.6%) cats and one out of fifty-nine (1.7%) dogs that
were positive by RT-PCR and sequencing, with the virus successfully isolated from the respiratory
swabs of one cat and one dog. Whole-genome sequences of SARS-CoV-2 obtained from all four
PCR-positive animals were unique variants grouping with genomes circulating among people with
COVID-19 in Texas. Re-sampling showed persistence of viral RNA for at least 25 d-post initial test.
Additionally, seven out of sixteen (43.8%) cats and seven out of fifty-nine (11.9%) dogs harbored
SARS-CoV-2 neutralizing antibodies upon initial sampling, with relatively stable or increasing titers
over the 2–3 months of follow-up and no evidence of seroreversion. The majority (82.4%) of infected
pets were asymptomatic. ‘Reverse zoonotic’ transmission of SARS-CoV-2 from infected people to
animals may occur more frequently than recognized.
Keywords in Portuguese
SARS-CoV-2Gatos
Cães
Zoonose reversa
Isolamento de vírus
Anticorpos neutralizantes
COVID-19
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