Author | Starling, Ana Lúcia Borges | |
Author | Gonçalves, Denise Utsch | |
Author | Magalhães, Vanessa Peruhype | |
Author | Reis, Jordana Coelho dos | |
Author | Lambertucci, José Roberto | |
Author | Labanca, Ludimila | |
Author | Pereira, Silvio Roberto Souza | |
Author | Martins, Marina L | |
Author | Ribas, João G | |
Author | Carvalho, Andréa Teixeira de | |
Author | Trindade, Bruno Caetano | |
Author | Faccioli, Lúcia Helena | |
Author | Proietti, Anna Bárbara de Freitas Carneiro | |
Author | Martins Filho, Olindo Assis | |
Access date | 2022-01-26T18:11:26Z | |
Available date | 2022-01-26T18:11:26Z | |
Document date | 2014 | |
Citation | STARLING, Ana LB et al.: Cytokines, chemokines and leukotrienes profile and signature analysis in HTLV-1 infection as na evidence of disease progression. Retrovirology , v. 11, Suppl 1, O37, 2014. doi:10.1186/1742-4690-11-S1-O37 | pt_BR |
ISSN | 1742-4690 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/50909 | |
Abstract in Portuguese | Background: A cross-sectional study evaluated the cytokines, chemokines and leukotrienes profiles as possible biomarkers of progression to HTLV-1 associated myelopathy (HAM).
Methods: Serum samples from 21 healthy blood donors (HBD), 27 asymptomatic carriers (ASC), 32 possible HAM (pHAM) and 28 HAM individuals were tested for cytokines (IL-6, IFN-γ, TNF-α, IL-2, IL-4 and IL-10), chemokines ( RANTES, MCP1, IL-8, MIG and IP-10) and leukotrienes (CysLTs and LTB-4). For each molecule tested, the HTLV-1 individuals were classified as low or high-producers taking the global median index of the HBD group as a cut off.
Results: When comparing AS and pHAM individuals, AS were high-producers of IP-10 and low-producers of RANTES; pHAM were high-producers of IL-2 and low of IL-8. Besides, AS individuals presented a strong positive correlation between the regulatory cytokines IL-10 with IL-4 and between both with the pro-inflammatory cytokines IL-2 and IL-6; a negative correlation was found between RANTES and IL-2. HAM were high-producers of IL-6, IFN-γ, IP-10, LTB4, IL-4, MIG, IL-10, IL-2, presented a positive correlation of TNF-α and IFN-γ with IL-6, but this group had a positive correlation of CysLT with IL-10, IL-4 and TNF-α, contrasting with other groups.
Discussion: HAM displayed a unique signature of inflammation, which was strengthened by CysLT and not counterbalanced by IL-4 and IL-10. This signature was observed in pHAM to a lower extent, becoming more evident in HAM. This profile may indicate disease progression and may serve as prognostic markers in future studies. | pt_BR |
Language | eng | pt_BR |
Publisher | BioMed Central | pt_BR |
Rights | open access | pt_BR |
Title | Cytokines, chemokines and leukotrienes profile and signature analysis in HTLV-1 infection as an evidence of disease progression | pt_BR |
Type | Article | pt_BR |
DOI | 10.1186/1742-4690-11-S1-O37 | |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Curso de Pós-Graduação em Infectologia e Medicina Tropical. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Curso de Pós-Graduação em Infectologia e Medicina Tropical. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Curso de Pós-Graduação em Infectologia e Medicina Tropical. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Curso de Pós-Graduação em Infectologia e Medicina Tropical. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Curso de Pós-Graduação em Infectologia e Medicina Tropical. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Estado de Minas Gerais. Fundação Centro de Hematologia e Hemoterapia de Minas Gerais. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Brasil. Hospital Sarah Kubitschek. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Farmácia. Ribeirão Preto, SP, Brazil. | pt_BR |
Affilliation | Estado de Minas Gerais. Fundação Centro de Hematologia e Hemoterapia de Minas Gerais. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil. | pt_BR |