Author | Carvalho, Márcia V. de | |
Author | Albuquerque, Cassiano F. Gonçalves de | |
Author | Silva, Adriana R. | |
Access date | 2022-02-07T14:38:34Z | |
Available date | 2022-02-07T14:38:34Z | |
Document date | 2021 | |
Citation | CARVALHO, Márcia V.; ALBUQUERQUE, Cassiano F. Gonçalves de; SILVA, Adriana R. PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases. International Journal of Molecular Sciences, v. 22, n. 805, p. 1 - 20, Jan. 2021. | pt_BR |
ISSN | 1661-6596 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/51050 | |
Language | spa | pt_BR |
Publisher | MDPI | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Lesão pulmonar | pt_BR |
Subject in Portuguese | Desconforto respiratório agudo | pt_BR |
Subject in Portuguese | Inflamação | pt_BR |
Subject in Portuguese | Alvos moleculares | pt_BR |
Subject in Portuguese | PPARY | pt_BR |
Title | PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases | pt_BR |
Type | Article | pt_BR |
DOI | 10.3390/ijms22020805 | |
Abstract | Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor
superfamily that regulate the expression of genes related to lipid and glucose metabolism and
inflammation. There are three members: PPAR , PPAR or PPAR
. PPAR
have several ligands.
The natural agonists are omega 9, curcumin, eicosanoids and others. Among the synthetic ligands,
we highlight the thiazolidinediones, clinically used as an antidiabetic. Many of these studies involve
natural or synthetic products in different pathologies. The mechanisms that regulate PPAR
involve
post-translational modifications, such as phosphorylation, sumoylation and ubiquitination, among
others. It is known that anti-inflammatory mechanisms involve the inhibition of other transcription
factors, such as nuclear factor kB(NF B), signal transducer and activator of transcription (STAT)
or activator protein 1 (AP-1), or intracellular signaling proteins such as mitogen-activated protein
(MAP) kinases. PPAR
transrepresses other transcription factors and consequently inhibits gene
expression of inflammatory mediators, known as biomarkers for morbidity and mortality, leading to
control of the exacerbated inflammation that occurs, for instance, in lung injury/acute respiratory
distress. Many studies have shown the therapeutic potentials of PPAR
on pulmonary diseases.
Herein, we describe activities of the PPAR
as a modulator of inflammation, focusing on lung injury
and including definition and mechanisms of regulation, biological effects and molecular targets,
and its role in lung diseases caused by inflammatory stimuli, bacteria and virus, and molecularbased
therapy. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro (UNIRIO). Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro (UNIRIO). Programa de Pós-Graduação em Biologia Molecular e Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Lung injury | pt_BR |
Subject | Acute respiratory distress | pt_BR |
Subject | Inflammation | pt_BR |
Subject | PPARY | pt_BR |
Subject | Molecular targets | pt_BR |
e-ISSN | 1422-0067 | |