Por favor, use este identificador para citar o enlazar este ítem:
https://www.arca.fiocruz.br/handle/icict/51293
Tipo
ArtículoDerechos de autor
Acceso restringido
Colecciones
Metadatos
Mostrar el registro completo del ítem
BISBENZYLISOQUINOLINE ALKALOIDS OF CISSAMPELOS SYMPODIALIS WITH ANTIVIRAL ACTIVITY AGAINST DENGUE VIRUS
Dengue virus
Antiviral activity
Warifteine
Methylwarifteine
Bisbenzylisoquinoline alkaloids
Autor
Afiliación
Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Department of Virology. Recife, PE, Brazil.
Federal University of Jequitinhonha and Mucuri Valleys. Department of Pharmacy. Diamantina, MG, Brazil.
Federal University of Jequitinhonha and Mucuri Valleys. Department of Pharmacy. Diamantina, MG, Brazil.
Federal University of Jequitinhonha and Mucuri Valleys. Department of Pharmacy. Diamantina, MG, Brazil.
Federal University of Jequitinhonha and Mucuri Valleys. Department of Pharmacy. Diamantina, MG, Brazil.
Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Department of Virology. Recife, PE, Brazil.
Universidade Federal Rural de Pernambuco. Laboratório de Bioprospecção Fotoquímica. Departamento de Química. Recife, PE, Brazil.
Federal University of Jequitinhonha and Mucuri Valleys. Department of Pharmacy. Diamantina, MG, Brazil.
Federal University of Jequitinhonha and Mucuri Valleys. Department of Pharmacy. Diamantina, MG, Brazil.
Federal University of Jequitinhonha and Mucuri Valleys. Department of Pharmacy. Diamantina, MG, Brazil.
Federal University of Jequitinhonha and Mucuri Valleys. Department of Pharmacy. Diamantina, MG, Brazil.
Federal University of Jequitinhonha and Mucuri Valleys. Department of Pharmacy. Diamantina, MG, Brazil.
Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Department of Virology. Recife, PE, Brazil.
Universidade Federal Rural de Pernambuco. Laboratório de Bioprospecção Fotoquímica. Departamento de Química. Recife, PE, Brazil.
Federal University of Jequitinhonha and Mucuri Valleys. Department of Pharmacy. Diamantina, MG, Brazil.
Resumen en ingles
A number of bisbenzyilisoquinoline alkaloids have been previously isolated from Cissampelos sympodialis (Menispermaceae). The tertiary alkaloid fraction of the rhizomes (TAFrz) was prepared and the major alkaloid warifteine was isolated. Five TAFrz subfractions in addition to warifteine were tested against Dengue virus (DENV). We then used an epithelial (Vero) cell line to evaluate the cytotoxicity and effective concentrations of the samples against DENV. All TAFrz subfractions were active, but subfraction 6 (a mixture of the alkaloids methylwarifteine and warifteine) in particular showed a promising antiviral effect against DENV-2 with an IC50 of 2.00 mg/ mL and a selectivity index (SI) of 10.74. Warifteine was the second most active sample and had an IC50 of 8.13 mg/mL and SI ¼ 10.94.
The antiviral activity of the samples compared favorably with that of 6-methylmercaptopurine riboside (IC50 ¼ 7.31 mg/mL and SI ¼ 11.8). These results suggest that bisbenzylisoquinoline alkaloids may prove interesting leading antiviral compounds.
Palabras clave en ingles
Cissampelos sympodialisDengue virus
Antiviral activity
Warifteine
Methylwarifteine
Bisbenzylisoquinoline alkaloids
Compartir