Author | Parolin, Cristina | |
Author | Virtuoso, Sara | |
Author | Giovanetti, Marta | |
Author | Angeletti, Silvia | |
Author | Ciccozzi, Massimo | |
Author | Borsetti, Alessandra | |
Access date | 2022-02-23T11:15:14Z | |
Available date | 2022-02-23T11:15:14Z | |
Document date | 2021 | |
Citation | PAROLIN, Cristina et al. Animal Hosts and Experimental Models of SARS-CoV-2 Infection. Chemotherapy, p. 1 - 9. 2021. | pt_BR |
ISSN | 0009-3157 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/51423 | |
Language | eng | pt_BR |
Publisher | Karger | pt_BR |
Rights | open access | |
Subject in Portuguese | Síndrome respiratória aguda grave coronavírus 2 | pt_BR |
Subject in Portuguese | Hospedeiros de animais | pt_BR |
Subject in Portuguese | Modelos animais | pt_BR |
Subject in Portuguese | Modelos de células | pt_BR |
Title | Animal Hosts and Experimental Models of SARS-CoV-2 Infection | pt_BR |
Type | Article | |
DOI | 10.1159/000515341 | |
Abstract | Viruses arise through cross-species transmission and can
cause potentially fatal diseases in humans. This is the case of
the severe acute respiratory syndrome coronavirus 2 (SARSCoV-
2) which recently appeared in Wuhan, China, and rapidly
spread worldwide, causing the outbreak of coronavirus
disease 2019 (COVID-19) and posing a global health emergency.
Sequence analysis and epidemiological investigations
suggest that the most likely original source of SARSCoV-
2 is a spillover from an animal reservoir, probably bats,
that infected humans either directly or through intermediate
animal hosts. The role of animals as reservoirs and natural
hosts in SARS-CoV-2 has to be explored, and animal models
for COVID-19 are needed as well to be evaluated for countermeasures
against SARS-CoV-2 infection. Experimental cells,
tissues, and animal models that are currently being used and
developed in COVID-19 research will be presented. | pt_BR |
Affilliation | Department of Molecular Medicine, University of Padova. Padova, Italy. | pt_BR |
Affilliation | National HIV/AIDS Research Center, Istituto Superiore di Sanità. Rome, Italy. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de referência de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome. Rome, Italy. | pt_BR |
Affilliation | Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome. Rome, Italy. | pt_BR |
Affilliation | National HIV/AIDS Research Center, Istituto Superiore di Sanità. Rome, Italy. | pt_BR |
Subject | Severe acute respiratory syndrome coronavirus 2 | pt_BR |
Subject | Animal hosts | pt_BR |
Subject | Animal models | pt_BR |
Subject | Cell models | pt_BR |