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A REVIEW ON NANOSTRUCTURED SILVER AS A BASIC INGREDIENT IN MEDICINE: PHYSICOCHEMICAL PARAMETERS AND CHARACTERIZATION
{111} Facetas
Mecanismo de ação
Ion de prata
Nanopartículas de prata
Controle de Qualidade
Agente virucida
{111} facets
Mechanism of action
Silver ion
Silver nanoparticles
Quality control
Virucidal agent
Afiliación
Oswaldo Cruz Foundation. Immunobiological Technology Institute. Physical Chemistry Laboratory. Rio de Janeiro, RJ, Brazil.
University of Calicut. School of Chemical and Physical Sciences. Department of Nanoscience and Technology. Thenhipalam, Kerala, India.
Oswaldo Cruz Foundation. National Institute for Quality Control in Health. Rio de Janeiro, RJ, Brazil.
University of Calicut. School of Chemical and Physical Sciences. Department of Nanoscience and Technology. Thenhipalam, Kerala, India.
Oswaldo Cruz Foundation. National Institute for Quality Control in Health. Rio de Janeiro, RJ, Brazil.
Resumen en portugues
Estudos recentes com nanopartículas de prata (AgNPs) e a história do metal prata como agente bactericida e virucida de amplo espectro, colocam a prata como um dos futuros candidatos biocidas no campo da nanomedicina para eliminar bactérias e vírus, principalmente os multirresistentes. Nesta revisão, descrevemos as várias morfologias de AgNPs e correlacionamos a atividade bactericida aprimorada com suas facetas {111} proeminentes. Além de priorizar a caracterização também discutimos a importância de quantificar AgNPs e conteúdo de íons de prata (Ag+) e seus diferentes mecanismos nos níveis químico, biológico, farmacológico e toxicológico. O mecanismo de ação das AgNPs contra várias bactérias e vírus, incluindo o SARSCoV-2, foi analisado a fim de entender sua eficácia como agente antimicrobiano com eficácia terapêutica e baixa toxicidade. Além disso, há a necessidade de caracterizar AgNPs e quantificar o conteúdo de Ag+ livre para a implementação de novos estudos sistemáticos desse promissor agente na nanomedicina e na prática clínica.
Resumen en ingles
Recent studies with silver nanoparticles (AgNPs) and the history of silver metal as a broad-spectrum bactericidal and virucidal agent, places silver as one of the future biocidal candidates in the field of nanomedicine to eliminate bacteria and viruses, especially multidrug resistant ones. In this review, we have described the various morphologies of AgNPs and correlated the enhanced bactericidal activity with their prominent {111} facets. In addition to prioritizing the characterization we have also discussed the importance of quantifying AgNPs and silver ion content (Ag+) and their different mechanisms at the chemical, biological, pharmacological, and toxicological levels. The mechanism of action of AgNPs against various bacteria and viruses including the SARSCoV-2 was analyzed in order to understand its effectiveness as an antimicrobial agent with therapeutic efficacy and low toxicity. Further, there is the need to characterize AgNPs and quantify the content of free Ag+ for the implementation of new systematic studies of this promising agent in nanomedicine and in clinical practice.
Palabras clave en portugues
Agente bactericida{111} Facetas
Mecanismo de ação
Ion de prata
Nanopartículas de prata
Controle de Qualidade
Agente virucida
Palabras clave en ingles
Bactericidal agent{111} facets
Mechanism of action
Silver ion
Silver nanoparticles
Quality control
Virucidal agent
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