Author | Zobrist, Stephanie | |
Author | Oliveira-Silva, Michelle | |
Author | Vieira, Alexia Martines | |
Author | Bansil, Pooja | |
Author | Gerth-Guyette, Emily | |
Author | Leader, Brandon T. | |
Author | Golden, Allison | |
Author | Slater, Hannah | |
Author | Cruz, Catherine Duran de Lucena | |
Author | Garbin, Eduardo | |
Author | Sagalovsky, Mariana | |
Author | Pal, Sampa | |
Author | Gupta, Vin | |
Author | Wolansky, Leo | |
Author | Dall'Acqua, Deusilene Souza Vieira | |
Author | Naveca, Felipe Gomes | |
Author | Nascimento, Valdinete Alves do | |
Author | Villalobos Salcedo, Juan Miguel | |
Author | Drain, Paul K. | |
Author | Costa, Alexandre Dias Tavares | |
Author | Domingo, Gonzalo J. | |
Author | Pereira, Dhélio | |
Access date | 2022-06-20T18:54:40Z | |
Available date | 2022-06-20T18:54:40Z | |
Document date | 2022 | |
Citation | ZOBRIST, Stephanie et al. Screening for severe acute respiratory syndrome coronavirus 2 in close contacts of individuals with confirmed infection: performance and operational considerations. The Journal of Infectious Diseases, p. 1-11, 20 May 2022. | pt_BR |
ISSN | 0022-1899 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/53379 | |
Language | eng | en_US |
Publisher | Oxford University Press | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Porto Velho | pt_BR |
Subject in Portuguese | Rondônia | pt_BR |
Subject in Portuguese | Allplex SARS-CoV-2 assay | pt_BR |
Subject in Portuguese | SalivaDirect | pt_BR |
Subject in Portuguese | Teste PADRÃO Q COVID-19 Ag | pt_BR |
Subject in Portuguese | LumiraDx SARS-CoV-2 Ag test | pt_BR |
Title | Screening for severe acute respiratory syndrome coronavirus 2 in close contacts of individuals with confirmed infection: performance and operational considerations | en_US |
Type | Article | pt_BR |
DOI | 10.1093/infdis/jiac204 | |
Abstract | Background. Point-of-care and decentralized testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to inform public health responses. Performance evaluations in priority use cases such as contact tracing can highlight trade-offs in test selection and testing strategies. Methods. A prospective diagnostic accuracy study was conducted among close contacts of coronavirus disease 2019 (COVID19) cases in Brazil. Two anterior nares swabs (ANS), a nasopharyngeal swab (NPS), and saliva were collected at all visits. Vaccination history and symptoms were assessed. Household contacts were followed longitudinally. Three rapid antigen tests and 1 molecular method were evaluated for usability and performance against reference reverse-transcription polymerase chain reaction (RT-PCR) on nasopharyngeal swab specimens. Results. Fifty index cases and 214 contacts (64 household) were enrolled. Sixty-five contacts were RT-PCR positive during ≥1 visit. Vaccination did not influence viral load. Gamma variants were most prevalent; Delta variants emerged increasingly during implementation. The overall sensitivity of evaluated tests ranged from 33% to 76%. Performance was higher among symptomatic cases and those with cycle threshold (Ct) values ,34 and lower among oligosymptomatic or asymptomatic cases. Assuming a 24-hour time to results for RT-PCR, the cumulative sensitivity of an anterior nares swab rapid antigen test was .70% and almost 90% after 4 days. Conclusions. The near-immediate time to results for antigen tests significantly offsets lower analytical sensitivity in settings where RT-PCR results are delayed or unavailable. | en_US |
Affilliation | Diagnostics - PATH. Seattle, WA, USA. | pt_BR |
Affilliation | Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil. | pt_BR |
Affilliation | Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil. | pt_BR |
Affilliation | Diagnostics - PATH. Seattle, WA, USA. | pt_BR |
Affilliation | Diagnostics - PATH. Seattle, WA, USA. | pt_BR |
Affilliation | Diagnostics - PATH. Seattle, WA, USA. | pt_BR |
Affilliation | Diagnostics - PATH. Seattle, WA, USA. | pt_BR |
Affilliation | Diagnostics - PATH. Seattle, WA, USA. | pt_BR |
Affilliation | Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil. | pt_BR |
Affilliation | Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil. | pt_BR |
Affilliation | Diagnostics - PATH. Seattle, WA, USA. | pt_BR |
Affilliation | Diagnostics - PATH. Seattle, WA, USA. | pt_BR |
Affilliation | Amazon.com. Seattle, WA, USA. | pt_BR |
Affilliation | The Rockefeller Foundation. Pandemic Prevention Institute. New York, NY, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Fiocruz Rondônia. Porto Velho, RO, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Fiocruz Rondônia. Porto Velho, RO, Brasil. | pt_BR |
Affilliation | University of Washington. Departments of Global Health and Medicine. Seattle, WA, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Diagnostics - PATH. Seattle, WA, USA. | pt_BR |
Affilliation | Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil. | pt_BR |
Subject | Porto Velho | en_US |
Subject | Rondônia | en_US |
Subject | Allplex SARS-CoV-2 assay | en_US |
Subject | SalivaDirect | en_US |
Subject | SD Biosensor STANDARD Q COVID-19 Ag | en_US |
Subject | LumiraDx SARS-CoV-2 Ag test | en_US |
Subject in Spanish | Porto Velho | es_ES |
Subject in Spanish | Rondônia | es_ES |
Subject in Spanish | Ensayo Allplex SARS-CoV-2 | es_ES |
Subject in Spanish | SalivaDirect | es_ES |
Subject in Spanish | SD Biosensor STANDARD Q COVID-19 Ag | es_ES |
Subject in Spanish | La Prueba LumiraDx SARS-CoV-2 Ag | es_ES |
DeCS | SARS-CoV-2 | pt_BR |
DeCS | COVID-19 | pt_BR |
DeCS | Reação em Cadeia da Polimerase Via Transcriptase Reversa | pt_BR |
DeCS | Kit de Reagentes para Diagnóstico | pt_BR |
e-ISSN | 1537-6613 | |