Author | Trøseid, Marius | |
Author | Hentzien, Maxime | |
Author | Ader, Florence | |
Author | Cardoso, Sandra Wagner | |
Author | Arribas, Jose R. | |
Author | Molina, Jean-Michel | |
Author | Mueller, Nicolas | |
Author | Hites, Maya | |
Author | Bonnet, Fabrice | |
Author | Manuel, Oriol | |
Author | Costagliola, Dominique | |
Author | Grinsztejn, Beatriz | |
Author | Olsen, Inge Christoffer | |
Author | Yazdapanah, Yazdan | |
Author | Calmy, Alexandra | |
Access date | 2022-07-21T10:50:02Z | |
Available date | 2022-07-21T10:50:02Z | |
Document date | 2022 | |
Citation | TRØSEID, Marius et al. Immunocompromised patients have been neglected in COVID-19 trials: a call for action. Clinical Microbiology and Infection, n. 22, p. 1-3, 2022. | pt_BR |
ISSN | 1469-0691 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/53896 | |
Description | Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Later version | https://www.arca.fiocruz.br/handle/icict/55854 | |
Rights | open access | pt_BR |
Title | Immunocompromised patients have been neglected in COVID-19 trials: a call for action | pt_BR |
Type | Preprint | pt_BR |
DOI | 10.1016/j.cmi.2022.05.005 | |
Abstract | Although several innovative and repurposed drugs have been approved for the treatment of COVID-19 during the last year, we still do not have evidence-based knowledge on the best therapeutic strategy to treat immunocompromised patients. Most treatment guidelines are structured to whether the disease state is mild, moderate, or severe, and not sufficiently according to host factors including host immunity. Whereas the Omicron variant causes less severe diseases in the general population, this is not necessarily the case for individuals with an impaired immune system, such as organ transplant recipients, patients with hematological malignancies, active cancer or primary immunodeficiency, or individuals treated with immunosuppressive drugs for a variety of medical conditions. | pt_BR |
Affilliation | Oslo University Hospital. Section of Clinical Immunology and Infectious Diseases. Oslo, Norway. | pt_BR |
Affilliation | Geneva University Hospitals. HIV/AIDS Research Unit. Geneva, Switzerland. | pt_BR |
Affilliation | Hospices Civils de Lyon. Hôpital de la Croix-Rousse. Département des Maladies Infectieuses et Tropicales. Lyon, France. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital La Paz. Infectious Diseases Unit. Madrid, Spain. | pt_BR |
Affilliation | Saint-Louis APHP. Infectious Diseases Department. Paris, France. | pt_BR |
Affilliation | University Hospital. Division of Infectious Diseases. Zurich, Switzerland. | pt_BR |
Affilliation | Université Libre de Bruxelles. Cliniques Universitaires de Bruxelles-Hôpital Érasme. Clinique des Maladies Infectieuses. Brussels, Belgium. | pt_BR |
Affilliation | CHU de Bordeaux and Université de Bordeaux. Bordeaux, France. | pt_BR |
Affilliation | Lausanne University Hospital. Infectious Diseases Service. Lausanne, Switzerland. | pt_BR |
Affilliation | Sorbonne Université. Institut Pierre Louis d'Epidémiologie et de Santé Publique. Paris, France. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Oslo University Hospital. Dept. of Research Support for Clinical Trials. Oslo, Norway. | pt_BR |
Affilliation | Université de Paris. Paris, France. | pt_BR |
Affilliation | Geneva University Hospitals. HIV/AIDS Research Unit. Geneva, Switzerland. | pt_BR |
Subject | Antivirals | pt_BR |
Subject | COVID-19 | pt_BR |
Subject | Guidelines | pt_BR |
Subject | Immunocompromised | pt_BR |
Subject | Trials | pt_BR |