Author | Miyamoto, Claudia Tiemi | |
Author | Gomes, Mônica Lúcia | |
Author | Marangon, Aline Vansan | |
Author | Araújo, Silvana Marques de | |
Author | Bahia, Maria Terezinha | |
Author | Martins Filho, Olindo Assis | |
Author | Lana, Marta de | |
Author | Toledo, Max Jean de Ornelas | |
Access date | 2022-08-03T18:48:19Z | |
Available date | 2022-08-03T18:48:19Z | |
Document date | 2008 | |
Citation | MIYAMOTO, Claudia Tiemi et al. Usefulness of the polymerase chain reaction for monitoring cure of mice infected with different Trypanosoma cruzi clonal genotypes following treatment with benznidazole. Exp Parasitol., v. 120, n. 1, p. 45-49, 2008. doi: 10.1016/j.exppara.2008.04.018. | pt_BR |
ISSN | 0014-4894 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/54368 | |
Language | eng | pt_BR |
Publisher | Academic Press | pt_BR |
Rights | restricted access | pt_BR |
Title | Usefulness of the polymerase chain reaction for monitoring cure of mice infected with different Trypanosoma cruzi clonal genotypes following treatment with benznidazole | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.exppara.2008.04.018 | |
Abstract | The capacity of the polymerase chain reaction (PCR) to detect the DNA of Trypanosoma cruzi was evaluated in 90 blood samples from BALB/c mice infected with T. cruzi cloned stocks of genotypes 19 and 20 (T cruzi 1) and 39 and 32 (T. cruzi 11), and treated with benznidazole. The results from the fresh blood examination, hemoculture, and ELISA allowed to group the treated animals into: cured (TC), dissociated (DIS) and non-cured (NC). The PCR detected T. cruzi DNA in 50.9%, 58.3% and 100.0% of the samples from TC, DIS and NC mice, respectively. These DNA possibly derives from live T cruzi or from recently lysed parasites, suggests that these animals are in fact not cured. The difference between the PCR results and results obtained using other techniques was statistically significant and independent of the parasite genotype. The PCR described has therefore potential to be used in cure control of treated patients. (C) 2008 Elsevier Inc. All rights reserved | pt_BR |
Affilliation | Universidade Estadual de Maringá. Centro de Ciencias da Saude. Departamento de Análises Clínicas. Maringá, Paraná, Brazil/Universidade Estadual de Maringa. Programa de Pós-graduação em Ciências da Saúde. Maringá, PR, Brazil | pt_BR |
Affilliation | Universidade Estadual de Maringa. Programa de Pós-graduação em Ciências da Saúde. Maringá, PR, Brazil | pt_BR |
Affilliation | Universidade Estadual de Maringá. Centro de Ciencias da Saude. Departamento de Análises Clínicas. Maringá, Paraná, Brazil | pt_BR |
Affilliation | Universidade Estadual de Maringá. Centro de Ciencias da Saude. Departamento de Análises Clínicas. Maringá, Paraná, Brazil/Universidade Estadual de Maringa. Programa de Pós-graduação em Ciências da Saúde. Maringá, PR, Brazil | pt_BR |
Affilliation | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Departamento de Ciências Biológicas. Ouro Preto, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Ouro Preto. Departamento de Análises Clínicas. Escola de Farmácia. Ouro Preto, MG, Brazil | pt_BR |
Affilliation | Universidade Estadual de Maringá. Centro de Ciencias da Saude. Departamento de Análises Clínicas. Maringá, Paraná, Brazil/ Universidade Estadual de Maringa. Programa de Pós-graduação em Ciências da Saúde. Maringá, PR, Brazil | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | cloned stocks | pt_BR |
Subject | cure control | pt_BR |
Subject | Chagas disease | pt_BR |
Subject | murine model | pt_BR |