Author | Torres, Lauana Ribas | |
Author | Capobianco, Lyana Rodrigues Pinto Lima | |
Author | Souza, Audrien Alves Andrade de | |
Author | Ribeiro, Camilla Rodrigues de Almeida | |
Author | Cascabulho, Cynthia | |
Author | Garzoni, Luciana Ribeiro | |
Author | Portari, Elyzabeth Avvad | |
Author | Gardel, Marcelo Aranha | |
Author | Batista, Marcelo Meuser | |
Author | Paula, Vanessa Salete de | |
Author | Souza, Elen Mello de | |
Access date | 2022-09-30T18:40:48Z | |
Available date | 2022-09-30T18:40:48Z | |
Document date | 2022 | |
Citation | TORRES, Lauana Ribas et al. ZIKV replication is differential in explants and cells of human placental which is suppressed by HSV-2 coinfection. Virology, v. 570, p. 45 - 56, 2022. | en_US |
ISSN | 0042-6822 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/54949 | |
Language | eng | en_US |
Publisher | Elsevier | en_US |
Rights | open access | |
Subject in Portuguese | ZIKVBR | en_US |
Subject in Portuguese | Coinfecção | en_US |
Subject in Portuguese | Suscetibilidade placentária | en_US |
Subject in Portuguese | Citocina | en_US |
Subject in Portuguese | Transmissão congênita | en_US |
Subject in Portuguese | HV-2BR | en_US |
Title | ZIKV replication is differential in explants and cells of human placental which is suppressed by HSV-2 coinfection | en_US |
Type | Article | |
DOI | 10.1016/j.virol.2022.03.004 | |
Abstract | During the Zika fever outbreak in Brazil in 2015–2016, only some babies from infected mothers had teratogenic
effects, suggesting that cofactors may influence congenital transmission. We investigated the ZIKV infection
profile in explants and isolated cells from full-term human placenta to infection with the Brazilian Zika virus
strain (ZIKVBR) and the effect of coinfection with the Brazilian Human alphaherpesvirus 2 strain (HSV-2BR) on
ZIKV replication. We found that the ZIKVBR infect the explants of amniotic and chorionic membranes, as well as
chorionic villi core, but not the trophoblasts layer. It was also observed that ZIKV replication was higher in
amniotic cells than chorionic and trophoblasts cells. Upon coinfection, the replication of ZIKVBR was reduced
according to exposed HSV-2BR load in trophoblasts cells and the levels of TNF-α and IL-6 cytokines were also
reduced. These findings suggest that the placental cell types and HSV-2BR coinfection may impact on ZIKV
replication. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laborat´orio de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laborat´orio de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Coordenação Diagnóstica de Anatomia Patológica e Citopatologia.Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Coordenação Diagnóstica de Anatomia Patológica e Citopatologia.Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Coordenação Diagnóstica de Anatomia Patológica e Citopatologia.Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ, Brasil. | en_US |
Subject | ZIKVBR | en_US |
Subject | HHV-2BR | en_US |
Subject | Coinfection | en_US |
Subject | Placental susceptibility | en_US |
Subject | Cytokine | en_US |
Subject | Congenital transmission | en_US |
Subject | HHV-2BR | en_US |