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https://www.arca.fiocruz.br/handle/icict/56089
GENOMIC ANALYSIS OF A PARASITE INVASION: COLONIZATION OF THE AMERICAS BY THE BLOOD FLUKE SCHISTOSOMA MANSONI
Author
Platt, Roy N.
Clec'h, Winka Le
Chevalier, Frédéric D.
McDew‐White, Marina
LoVerde, Philip T.
Assis, Rafael Ramiro de
Oliveira, Guilherme Corrêa de
Kinung'hi, Safari
Djirmay, Amadou Garba
Steinauer, Michelle L.
Gouvras, Anouk
Rabone, Muriel
Allan, Fiona
Webster, Bonnie L.
Webster, Joanne P.
Emery, Aidan M.
Rollinson, David
Anderson, Timothy J. C.
Clec'h, Winka Le
Chevalier, Frédéric D.
McDew‐White, Marina
LoVerde, Philip T.
Assis, Rafael Ramiro de
Oliveira, Guilherme Corrêa de
Kinung'hi, Safari
Djirmay, Amadou Garba
Steinauer, Michelle L.
Gouvras, Anouk
Rabone, Muriel
Allan, Fiona
Webster, Bonnie L.
Webster, Joanne P.
Emery, Aidan M.
Rollinson, David
Anderson, Timothy J. C.
Affilliation
Texas Biomedical Research Institute. San Antonio, Texas, USA
Texas Biomedical Research Institute. San Antonio, Texas, USA
Texas Biomedical Research Institute. San Antonio, Texas, USA
Texas Biomedical Research Institute. San Antonio, Texas, USA
University of Texas Health Science Center. San Antonio Texas, USA
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/ Instituto Tecnológico Vale. Belém, PA, Brazil
National Institute for Medical Research. Mwanza Tanzania
Réseau International Schistosomiases Environnemental Aménagement et Lutte (RISEAL), Niamey Niger
Western University of Heath Sciences. Corvallis, Oregon, USA
Natural History Museum. London, UK
Natural History Museum. London, UK
Department of Pathobiology and Population Sciences. Royal Veterinary College. Centre for Emerging, Endemic and Exotic Diseases. University of London. Hertfordshire, UK/London Centre for Neglected Tropical Disease Research. Imperial College London. School of Public Health. London, UK
Natural History Museum. London, UK/ London Centre for Neglected Tropical Disease Research. Imperial College London. School of Public Health. London, UK
Department of Pathobiology and Population Sciences. Royal Veterinary College. Centre for Emerging. Endemic and Exotic Diseases. University of London. Hertfordshire, UK/London Centre for Neglected Tropical Disease Research. Imperial College London. School of Public Health. London, UK
Natural History Museum. London, UK/London Centre for Neglected Tropical Disease Research. Imperial College London. School of Public Health. London, UK
Natural History Museum. London, UK/London Centre for Neglected Tropical Disease Research. Imperial College London. School of Public Health. London, UK
Texas Biomedical Research Institute. San Antonio. Texas, USA
Texas Biomedical Research Institute. San Antonio, Texas, USA
Texas Biomedical Research Institute. San Antonio, Texas, USA
Texas Biomedical Research Institute. San Antonio, Texas, USA
University of Texas Health Science Center. San Antonio Texas, USA
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/ Instituto Tecnológico Vale. Belém, PA, Brazil
National Institute for Medical Research. Mwanza Tanzania
Réseau International Schistosomiases Environnemental Aménagement et Lutte (RISEAL), Niamey Niger
Western University of Heath Sciences. Corvallis, Oregon, USA
Natural History Museum. London, UK
Natural History Museum. London, UK
Department of Pathobiology and Population Sciences. Royal Veterinary College. Centre for Emerging, Endemic and Exotic Diseases. University of London. Hertfordshire, UK/London Centre for Neglected Tropical Disease Research. Imperial College London. School of Public Health. London, UK
Natural History Museum. London, UK/ London Centre for Neglected Tropical Disease Research. Imperial College London. School of Public Health. London, UK
Department of Pathobiology and Population Sciences. Royal Veterinary College. Centre for Emerging. Endemic and Exotic Diseases. University of London. Hertfordshire, UK/London Centre for Neglected Tropical Disease Research. Imperial College London. School of Public Health. London, UK
Natural History Museum. London, UK/London Centre for Neglected Tropical Disease Research. Imperial College London. School of Public Health. London, UK
Natural History Museum. London, UK/London Centre for Neglected Tropical Disease Research. Imperial College London. School of Public Health. London, UK
Texas Biomedical Research Institute. San Antonio. Texas, USA
Abstract
Schistosoma mansoni, a snail‐borne, blood fluke that infects humans, was introduced into the Americas from Africa during the Trans‐Atlantic slave trade. As this parasite shows strong specificity to the snail intermediate host, we expected that adaptation to South American Biomphalaria spp. snails would result in population bottlenecks and strong signatures of selection. We scored 475,081 single nucleotide variants in 143 S. mansoni from the Americas (Brazil, Guadeloupe and Puerto Rico) and Africa (Cameroon, Niger, Senegal, Tanzania, and Uganda), and used these data to ask: (i) Was there a population bottleneck during colonization? (ii) Can we identify signatures of selection associated with colonization? (iii) What were the source populations for colonizing parasites? We found a 2.4‐ to 2.9‐fold reduction in diversity and much slower decay in linkage disequilibrium (LD) in parasites from East to West Africa. However, we observed similar nuclear diversity and LD in West Africa and Brazil, suggesting no strong bottlenecks and limited barriers to colonization. We identified five genome regions showing selection in the Americas, compared with three in West Africa and none in East Africa, which we speculate may reflect adaptation during colonization. Finally, we infer that unsampled populations from central African regions between Benin and Angola, with contributions from Niger, are probably the major source(s) for Brazilian S. mansoni. The absence of a bottleneck suggests that this is a rare case of a serendipitous invasion, where S. mansoni parasites were pre‐adapted to the Americas and able to establish with relative ease.
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