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GLOBAL GENOMIC EPIDEMIOLOGY OF ESCHERICHIA COLI (EXPEC) ST38 LINEAGE REVEALED A VIRULOME ASSOCIATED WITH HUMAN INFECTIONS
Zoonoses
Alto risco
Epidemiologia genômica
Ilha de alta patogenicidade
Genoma acessório
ETT2
Zoonosis
High-risk
Genomic epidemiology
High-pathogenicity island
Accessory genome
ETT2
Afiliación
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil.
Universidade Federal de Roraima. Centro de Ciências da Saúde. Boa Vista, RR, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil.
Universidade Federal de Roraima. Centro de Ciências da Saúde. Boa Vista, RR, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil.
Resumen en ingles
Most of the extraintestinal human infections worldwide are caused by
specific extraintestinal pathogenic Escherichia coli (ExPEC) lineages, which also present a zoonotic
character. One of these lineages belongs to ST38, a high-risk globally disseminated ExPEC. To get
insights on the aspects of the global ST38 epidemiology and evolution as a multidrug-resistant and
pathogenic lineage concerning the three axes of the One Health concept (humans, animals, and natural
environments), this study performed a global phylogenomic analysis on ST38 genomes. Methods:
A phylogenetic reconstruction based on 376 ST38 genomes recovered from environments, humans,
livestock, and wild and domestic animals in all continents throughout three decades was performed.
The global information concerning the ST38 resistome and virulome was also approached by in silico
analyses. Results: In general, the phylogenomic analyses corroborated the zoonotic character of the
ExPEC ST38, since clonal strains were recovered from both animal and human sources distributed
worldwide. Moreover, our findings revealed that, independent of host sources and geographic origin,
the genomes were distributed in two major clades (Clades 1 and 2). However, the ST38 accessory
genome was not strictly associated with clades and sub-clades, as found for the type 2 T3SS ETT2
that was evenly distributed throughout Clades 1 and 2. Of note was the presence of the Yersinia
pestis-like high-pathogenicity island (HPI) exclusively in the major Clade 2, in which prevails most of
the genomes from human origin recovered worldwide (2000 to 2020). Conclusions: This evidence
corroborates the HPI association with successful E. coli ST38 establishment in human infections.
Palabras clave en portugues
FilogenômicaZoonoses
Alto risco
Epidemiologia genômica
Ilha de alta patogenicidade
Genoma acessório
ETT2
Palabras clave en ingles
PhylogenomicsZoonosis
High-risk
Genomic epidemiology
High-pathogenicity island
Accessory genome
ETT2
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