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FIRST REPORT OF FUNGAL MENINGOENCEPHALITIS BY PENICILLIUM CHRYSOGENUM IN BRAZIL
Oliveira, Rômulo Vieira Mello de et al. | Date Issued: 2023
Author
Oliveira, Rômulo Vieira Mello de
Corrêa-Moreira, Danielly
Mendes, Túlio Vieira
Costa, Gisela Lara da
Vieira, Renata de Magalhães
Buchele, Cynthia Miranda Nascimento
Lins, Rodrigo Schrage
Ferreira, Ana Beatriz Teixeira Brandão Camello
Veira, Daniela Barbosa
Pedroso, Rafael Santos de Aragão
Faria, Vinícius Tadeu Dias Pereira de
Oliveira, Manoel Marques Evangelista
Affilliation
Hospital Naval Marcilio Dias. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Marcilio Dias Naval Hospital. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos. Rio de Janeiro, RJ, Brasil.
Hospital Naval Marcilio Dias. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.
Hospital Naval Marcilio Dias. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.
Hospital Naval Marcilio Dias. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.
Hospital Naval Marcilio Dias. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.
Hospital Naval Marcilio Dias. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.
Hospital Naval Marcilio Dias. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.
Hospital Naval Marcilio Dias. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos. Rio de Janeiro, RJ, Brasil.
Abstract
Introduction: Fungal infections of the central nervous system present a variety of clinical syndromes, such as meningitis, encephalitis, raised intracranial pressure with a nonspecific presentation, and, in the last two decades, have increased the incidence of these fungal infections. Fungal meningoencephalitis is frequently associated with Cryptococcus, but this report stands out for presenting one species of Penicillium genus. Objectives: Here, we present the first case of meningoencephalitis associated with brain injury caused by Penicillium chrysogenum, in a patient who is immunocompetent and was admitted to Hospital Naval Marcílio Dias, Rio de Janeiro, Brazil. Methods: To identify the fungal species, we performed phenotypic and genotypic methodologies, from the culture to the sequencing of internal transcribed spacer region, and β-tubulin gene, a rare fungus in cerebrospinal fluid cultures, belonging to the genus Penicillium, was identified. Conclusion: We highlight the importance of the first report of meningoencephalitis caused by P. chrysogenum in a patient who is immunocompetent, registered in Brazil. We also emphasize the need for further studies to determine an effective treatment with the least possible side effects for patients infected by fungi that are rarely related to the most severe forms of invasive infections.
Keywords in Portuguese
Infeções fungais
Paciente imunocompetente
Meningoencefalite
Penicillium
Penicillium chrysogenum
 
Keywords
Fungal infections
Immunocompetent patient
Meningoencephalitis
Penicillium
Penicillium chrysogenum
 
Publisher
Elsevier Open Access
Citation
OLIVEIRA, Rômulo Vieira Mello de et al. First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil. International Journal of Infectious Diseases, v. 126, p. 94-97, Jan. 2023.
DOI
10.1016/j.ijid.2022.11.015
ISSN
1201-9712