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https://www.arca.fiocruz.br/handle/icict/5653
MYOFIBROBLASTS IN SCHISTOSOMAL PORTAL FIBROSIS OF MAN.
Músculo Liso/patologia
Veia Porta/patologia
Adolescente
Adulto
Biópsia
Feminino
Fibrose
Humanos
Hepatopatias/patologia
Masculino
Meia-Idade
Esplenopatias/patologia
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Laboratoire Marcel Merieux. Lyon, France
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Laboratoire Marcel Merieux. Lyon, France
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract
Myofibroblasts, cells with intermediate features between smooth muscle cells and fibroblasts, have been described as an important cellular component of schistosomal portal fibrosis. The origin, distribution and fate of myofibroblasts were investigated by means of light, fluorescent, immunoenzymatic and ultrastructural techniques in wedge liver biopsies from 68 patients with the hepatosplenic form of schistosomiasis. Results demonstrated that the presence of myofibroblasts varied considerably from case to case and was always related to smooth muscle cell dispersion, which occurred around medium-sized damaged portal vein branches. By sequential observation of several cases, it was evident that myofibroblasts derived by differentiation of vascular smooth muscle and gradually tended to disappear, some of them further differentiating into fibroblasts. Thus, in schistosomal pipestem fibrosis myofibroblasts appear as transient cells, focally accumulated around damaged portal vein branches, and do not seem to have by themselves any important participation in the pathogenesis of hepatosplenic schistosomiasis.
DeCS
Fibroblastos/patologiaMúsculo Liso/patologia
Veia Porta/patologia
Adolescente
Adulto
Biópsia
Feminino
Fibrose
Humanos
Hepatopatias/patologia
Masculino
Meia-Idade
Esplenopatias/patologia
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