Autor | Andrade, Zilton de Araújo | |
Autor | Silva, Luciana Menezes da | |
Autor | Souza, Márcia Maria de | |
Data de acesso | 2012-10-16T19:00:30Z | |
Data de disponibilização | 2012-10-16T19:00:30Z | |
Data do publicação | 1997 | |
Citação | ANDRADE, Z.A.; SILVA, L.M.; de SOUZA, M.M. An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver). Memórias do Instituto Oswaldo Cruz, v. 92, n. 5, p. 699-706, sep.-oct. 1997. | pt_BR |
ISSN | 0074-0276 | |
URI | https://www.arca.fiocruz.br/handle/icict/5673 | |
Idioma | eng | pt_BR |
Direito Autoral | open access | |
Título | An experimental approach to the pathogenesis of "pipestem" fibrosis (Symmers' fibrosis of the liver) | pt_BR |
Tipo do documento | Article | pt_BR |
Resumo em Inglês | Pathogenesis of schistosomal hepatic fibrosis ("pipestem" fibrosis of the liver) was investigated by means of the murine model. Although worm load appears as the main pathogenetic factor, alone it is not sufficient to produce that characteristic lesion. By comparing the findings in animals with heavy and prolonged Schistosoma mansoni infection, which developed or not "pipestem" fibrosis, it was observed that the lesion was more frequent in intact animals than in the splenectomized one. However, the size of the spleen, the number of recovered worms, the number of eggs per gram of liver tissue, the level of serum idiotype and anti-idiotype antibodies, the size and volume of periovular granulomas formed in the liver, all that failed to show statistically significant differences between the two groups. After analysing all these data, other factors, that apparently have been hitherto negleted, rested to explain the findings. Among them, the timing and sequence of the egg-induced intrahepatic vascular changes seemed crucial. The sequential development of intrahepatic portal vein obstruction, followed by the opening of periportal collateral veins and the continous arrival of schistosome eggs going to be lodged into the latter, appeared as essential steps in the pathogenesis of "pipestem" fibrosis. | pt_BR |
Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Palavras-chave em inglês | Schistosoma mansoni | pt_BR |
Palavras-chave em inglês | Pipestem fibrosis | pt_BR |
Palavras-chave em inglês | Pathogenesis | pt_BR |
DeCS | Cirrose Hepática/parasitologia | pt_BR |
DeCS | Schistosoma mansoni | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Granuloma | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Contagem de Ovos de Parasitas/estatística & dados numéricos | pt_BR |