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Autor | Andrade, Sonia Gumes | |
Autor | Carneiro Filho, Aydano | |
Autor | Souza, André J. Maia de | |
Autor | Lima, Elianita Suzart de | |
Autor | Andrade, Zilton de Araújo | |
Fecha de acceso | 2012-10-16T19:16:09Z | |
Fecha de disponibilización | 2012-10-16T19:16:09Z | |
Fecha de publicación | 1997 | |
Referencia | ANDRADE, S. G. et al. Influence of treatment with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi. International Journal of Experiemental Pathology, v. 78, n. 6, p. 391-9, dec. 1997. | pt_BR |
ISSN | 0959-9673 | |
URI | https://www.arca.fiocruz.br/handle/icict/5674 | |
Idioma | eng | pt_BR |
Derechos de autor | open access | |
Título | Influence of treatment with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi. | pt_BR |
Tipo del documento | Article | pt_BR |
Resumen en Inglés | Latent Trypanosoma cruzi infection may be reactivated in immunosuppressed individuals, with unusual clinical patterns, such as meningoencephalitis, pseudo neoplastic lesions in the central nervous system, and myocarditis with numerous parasites in the heart muscle. To investigate this problem 68 Swiss mice chronically infected with different strains of T. cruzi were treated with different combinations of immunosuppressive drugs (azathioprine, cyclosporine and betamethasone), in such a way as to imitate the situation during post transplantation treatment. Mortality varied from 6 to 25% in treated mice. There were no deaths in untreated controls. Normal mice have been submitted to the same schedules of immunosuppression as controls of treatment and no deaths were registered during treatment. Chronically infected mice showed significant elevation of total number of leukocytes and lymphocytes in comparison with intact controls; a significant decrease in blood leukocytes and lymphocytes occurred post-treatment in two of the treated experimental groups. Exacerbation of myocarditis and myositis and a high incidence of brain lesions, with focal necrosis, granulomatous lesions and glial proliferation even in the absence of parasites were present in immunosuppressed mice but not in infected controls. Although differing in some aspects from Chagas' disease in immunosuppressed humans, the murine model did show some features that resembled it, especially the peculiar pattern of central nervous system involvement. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Palavras clave en Inglês | Trypanosoma cruzi | pt_BR |
Palavras clave en Inglês | Immunosuppression | pt_BR |
Palavras clave en Inglês | Azathioprine | pt_BR |
Palavras clave en Inglês | Cyclosporine | pt_BR |
Palavras clave en Inglês | Betamethasone | pt_BR |
DeCS | Doença de Chagas/imunologia | pt_BR |
DeCS | Modelos Animais de Doenças | pt_BR |
DeCS | Imunossupressores/efeitos adversos | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Anticorpos Anti-Helmínticos/sangue | pt_BR |
DeCS | Azatioprina/efeitos adversos | pt_BR |
DeCS | Betametasona/efeitos adversos | pt_BR |
DeCS | Encéfalo/parasitologia | pt_BR |
DeCS | Doença Crônica | pt_BR |
DeCS | Ciclosporina/efeitos adversos | pt_BR |
DeCS | Contagem de Leucócitos | pt_BR |
DeCS | Contagem de Linfócitos | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Camundongos Endogâmicos | pt_BR |
DeCS | Recidiva | pt_BR |
DeCS | Transplante | pt_BR |