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2030-12-31
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MALARIA RESILIENCE IN SOUTH AMERICA: EPIDEMIOLOGY, VECTOR BIOLOGY, AND IMMUNOLOGY INSIGHTS FROM THE AMAZONIAN INTERNATIONAL CENTER OF EXCELLENCE IN MALARIA RESEARCH NETWORK IN PERU AND BRAZIL
Torres, Katherine et al. | Data do documento: 2022
Autor(es)
Torres, Katherine
Ferreira, Marcelo U
Castro, Marcia C
Escalante, Ananias A
Conn, Jan E
Villasis, Elizabeth
Araujo, Maisa da Silva
Almeida, Gregorio
Rodrigues, Priscila T
Corder, Rodrigo M
Fernandes, Anderson R J
Calil, Priscila R
Ladeia, Winni A
Garcia-Castillo, Stefano S
Gomez, Joaquin
Antonelli, Lis Ribeiro do Valle
Gazzinelli, Ricardo Tostes
Golenbock, Douglas Taylor
Llanos-Cuentas, Alejandro
Gamboa, Dionicia
Vinetz, Joseph M
Afiliação
Institute of Tropical Medicine Alexander von Humboldt. Universidad Peruana Cayetano Heredia. Lima, Peru/Laboratorios de Investigación y Desarrollo. Facultad de Ciencias y Filosofía. Universidad Peruana Cayetano Heredia. Lima, Peru.
Department of Parasitology. Institute of Biomedical Sciences. University of São Paulo. Sao Paulo, SP, Brazil.
Department of Global Health and Population. Harvard T. H. Chan School of Public Health. Boston. MA, USA.
Department of Biology and Institute for Genomics and Evolutionary Medicine. Temple University. Philadelphia, PA, USA.
Department of Biomedical Sciences. School of Public Health. University at Albany. State University of New York. Albany, NY, USA/Wadsworth Center. New York State Department of Health., Albany, NY, USA
Institute of Tropical Medicine Alexander von Humboldt. Universidad Peruana Cayetano Heredia. Lima, Peru/Laboratorios de Investigación y Desarrollo. Facultad de Ciencias y Filosofía. Universidad Peruana Cayetano Heredia. Lima, Peru.
Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil
Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil
Department of Parasitology. Institute of Biomedical Sciences. University of São Paulo. Sao Paulo, SP, Brazil.
Department of Parasitology. Institute of Biomedical Sciences. University of São Paulo. Sao Paulo, SP, Brazil.
Department of Parasitology. Institute of Biomedical Sciences. University of São Paulo. Sao Paulo, SP, Brazil.
Department of Parasitology. Institute of Biomedical Sciences. University of São Paulo. Sao Paulo, SP, Brazil.
Department of Parasitology. Institute of Biomedical Sciences. University of São Paulo. Sao Paulo, SP, Brazil.
Laboratorios de Investigación y Desarrollo. Facultad de Ciencias y Filosofía. Universidad Peruana Cayetano Heredia. Lima, Peru.
Laboratorios de Investigación y Desarrollo. Facultad de Ciencias y Filosofía. Universidad Peruana Cayetano Heredia. Lima, Peru.
Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil
Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School. Worcester, MA, USA
Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School. Worcester, MA, USA
Institute of Tropical Medicine Alexander von Humboldt. Universidad Peruana Cayetano Heredia. Lima, Peru
Institute of Tropical Medicine Alexander von Humboldt. Universidad Peruana Cayetano Heredia. Lima, Peru/Laboratorios de Investigación y Desarrollo. Facultad de Ciencias y Filosofía. Universidad Peruana Cayetano Heredia. Lima, Peru
Institute of Tropical Medicine Alexander von Humboldt. Universidad Peruana Cayetano Heredia. Lima, Peru/Laboratorios de Investigación y Desarrollo. Facultad de Ciencias y Filosofía. Universidad Peruana Cayetano Heredia. Lima, Peru/Section of Infectious Diseases. Department of Internal Medicine. Yale School of Medicine. New Haven, CT, USA.
Resumo em Inglês
The 1990s saw the rapid reemergence of malaria in Amazonia, where it remains an important public health priority in South America. The Amazonian International Center of Excellence in Malaria Research (ICEMR) was designed to take a multidisciplinary approach toward identifying novel malaria control and elimination strategies. Based on geographically and epidemiologically distinct sites in the Northeastern Peruvian and Western Brazilian Amazon regions, synergistic projects integrate malaria epidemiology, vector biology, and immunology. The Amazonian ICEMR's overarching goal is to understand how human behavior and other sociodemographic features of human reservoirs of transmission-predominantly asymptomatically parasitemic people-interact with the major Amazonian malaria vector, Nyssorhynchus (formerly Anopheles) darlingi, and with human immune responses to maintain malaria resilience and continued endemicity in a hypoendemic setting. Here, we will review Amazonian ICEMR's achievements on the synergies among malaria epidemiology, Plasmodium-vector interactions, and immune response, and how those provide a roadmap for further research, and, most importantly, point toward how to achieve malaria control and elimination in the Americas.
Editor
American Society of Tropical Medicine and Hygiene
Referência
TORRES, Katherine et al. Malaria Resilience in South America: Epidemiology, Vector Biology, and Immunology Insights from the Amazonian International Center of Excellence in Malaria Research Network in Peru and Brazil. Am J Trop Med Hyg., v. 107, Suppl 4, p. 168-181, 2022. doi: 10.4269/ajtmh.22-0127.
ISSN
0002-9637 American Society of Tropical Medicine and Hygiene